Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Gut microbiota composition in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives

PROVIDER: PRJEB38765 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	ERR4221530.fastq.gz	Fastqsanger.gz
	ERR4221540.fastq.gz	Fastqsanger.gz
	ERR4221550.fastq.gz	Fastqsanger.gz
	ERR4221560.fastq.gz	Fastqsanger.gz
	ERR4221570.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 236

Similar Datasets

Transcriptional profiling in facioscapulohumeral muscular dystrophy to identify candidate biomarkers

Project description:Facioscapulohumeral muscular dystrophy (FSHD) is a progressive neuromuscular disorder caused by contractions of repetitive elements within the macrosatellite D4Z4 on chromosome 4q35. In order to develop mRNA-based biomarkers of affected muscles, we used GeneChip Gene 1.0 ST arrays for global analysis of gene expression in muscle biopsy specimens obtained from FSHD subjects and their unaffected first degree relatives. FSHD typically affects biceps muscles more severely than deltoid muscles. To examine muscle-specific expression changes associated with FSHD while controlling for background genetic variation, we analyzed RNA extracted from both biceps and deltoids of FSHD subjects and unaffected first-degree relatives.

2012-09-19 | E-GEOD-36398 | biostudies-arrayexpress

Autoimmune family study

Project description:Patients with autoimmune disorders exhibit highly reproducible gene expression profiles in their peripheral blood mononuclear cells. These signatures may result from chronic inflammation, other disease manifestations, or may reflect family resemblance. To test the latter hypothesis, we determined gene expression profiles in unaffected first-degree relatives of individuals with autoimmune disease. Gene expression profiles in unaffected first-degree relatives resembled the profiles found in individuals with autoimmune diseases. A high percentage of differentially expressed genes in unaffected first-degree relatives were previously identified as autoimmune signature genes. Examination of the linear regression relationship of gene transcript levels between parent-offspring pairs revealed that autoimmune signature genes display high levels of family resemblance. Taken together, these results support the hypothesis that these variations in gene transcript levels are associated with family resemblance rather than clinical manifestations of disease. Keywords: Gene expression profiling

2005-10-18 | GSE3459 | GEO

Autoimmune family study

2010-06-09 | E-GEOD-3459 | biostudies-arrayexpress

Transcriptional profiling in facioscapulohumeral muscular dystrophy to identify candidate biomarkers

2012-09-19 | GSE36398 | GEO

Expression profiling in VCP-associated myopathy

Project description:Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPFD) is caused by mutations in the Valosin Containing Protein (VCP) gene on chromosome 9p12-13. To elucidate affected signaling transduction axes in IBMPFD, we determined expression profiles using microarray technology in quadriceps muscle from patients and unaffected relatives. Muscle from 10 individuals (7 affected, 3 unaffected first degree relatives) was obtained after informed consent for the muscle biopsy was obtained.

2012-07-18 | E-GEOD-30806 | biostudies-arrayexpress

Gut microbiome of celiac disease patients

Project description:Composition and functional variation in gut microbiome of celiac disease patients and first-degree relatives

| PRJEB5780 | ENA

First Degree Relatives (FDRs) of Patients with Celiac Disease Harbour an Intestinal Transcriptomic Signature that Might Protect Them from Enterocyte Damage

Project description:Patients with Celiac Disease, first degree relatives of celiac patients and control groups displayed significant differential gene expression.

2019-03-21 | GSE112102 | GEO

human gut metagenome

Project description:Gut Microbiome composition Predicts Risk of Crohn's disease in Healthy First-Degree Relatives

| PRJNA685746 | ENA

Bipolar disorder and lithium-induced gene expression in two peripheral cell models

Project description:Bipolar disorder is a severe and heritable psychiatric disorder and affects up to 1% of the population worldwide. Lithium is recommended as first-line treatment for the maintenance treatment of bipolar-affective disorder in current guidelines, its molecular modes of action are however poorly understood. Cell models derived from bipolar patients could prove useful to gain more insight in the molecular mechanisms of bipolar disorder and the common pharmacological treatments. As primary neuronal cell lines cannot be easily derived from patients, peripheral cell models should be evaluated in their usefulness to study pathomechanisms and the mode of action of medication as well as in regard to develop biomarkers for diagnosis and treatment response.

2018-12-01 | GSE66196 | GEO

human gut metagenome

Project description:Small Intestinal And Faecal Microbiota Of Adult Celiac Patients And First-Degree Relatives.

| PRJNA385735 | ENA