Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-seq of zebrafish adult MCU mutant hearts

ABSTRACT: RNA-seq of zebrafish adult MCU mutant hearts

PROVIDER: PRJEB40865 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Effect of TMEM43 overexpression on gene expression in adult zebrafish hearts

Project description:To determine transcriptional changes caused by the overexpression of wild-type and mutant TMEM43 and to gain insights into the mechanisms responsible for the phenotype of arrhythmogenic cardiomyopathy We performed RNA-sequencing in adult zebrafish hearts

2022-12-31 | GSE208408 | GEO

RNAseq of regenerating yap mutant zebrafish hearts

Project description:RNAseq of regenerating yap mutant zebrafish hearts

| PRJNA447594 | ENA

Transcriptome analysis of heart regeneration in adult zebrafish

Project description:After heart injury, adult zebrafish can perfectly regenerate its heart without any scar tissue left. We performed 100bp*2, paired-end, strand-specific, polyA-positive RNA-seq on hearts from 2 group of adult zebrafish, in which one was sham group and the other 7 days after heart tip amputation (7dpa). We found pathways involving hydrogen peroxidate related functions significantly up-regulated in 7dpa group, indicating its role in heart regeneration. RNA-seq: hearts from sham or 7dpa adult zebrafish

2014-12-24 | E-GEOD-50203 | biostudies-arrayexpress

Transcriptome analysis on wild type and mvp mutant zebrafish ventricles at 7dpa by Next Generation Sequencing

Project description:In contrast to mammals, the adult zebrafish hearts can regenerate within a short period. Upregulation of major vault protein (Mvp) expression after ventricle resection. To determine the impact of loss of mvp on transcriptome during heart regeneration, we pursued transcriptome analysis (RNA-Seq) on wild type and mvp mutant zebrafish hearts at 7 day-post-amputation.

2020-09-01 | GSE157170 | GEO

RNA seq analysis from the kidney of pycard mutant adult zebrafish in Mycobacterium marinum infection

Project description:Zebrafish / Mycobacterium marinum model is useful in modeling human tuberculosis, as zebrafish recapitulate several aspects of the disease. We generated a mutant line for the inflammasome adaptor gene pycard to study the loss of inflammasome signaling in adult zebrafish M. marinum infection. We discovered a number of immunity related genes up- or downregulated in mutant pycard zebrafish in comparison to WT control siblings. The RNA-seq was conducted using a low dose infection (approximately 30 CFU) at 4 weeks post infection, from the kidney of adult male fish. Mock injected controls received PBS instead of bacteria.

2024-07-04 | GSE189627 | GEO

Early gene expression of regenerating zebrafish hearts following water or atropine treatment

Project description:We report global RNA expression profiles from whole zebrafish hearts 24 hours after ventricle amputation. Zebrafish were exposed to atropine or water following surgery. 15 zebrafish hearts were pooled per microarray chip. Amputated hearts of zebrafish exposed to atropine was compared to hearts of zebrafish exposed to water.

2015-06-11 | E-GEOD-69775 | biostudies-arrayexpress

leptin b and its regeneration enhancer illustrate regenerative features of zebrafish hearts

Project description:We obtained uninjured and injured hearts transcritome profiles of wild-type and LEN deletion mutant zebrafish. Note that LEN is the leptin b-linked regenreation enhancer located about 6kb upstream of leptin b gene.

2022-04-03 | GSE199697 | GEO

Transcriptome analysis of heart regeneration in adult zebrafish

2014-12-24 | GSE50203 | GEO

Proteomic analysis of extracellular matrix remodeling during zebrafish heart regeneration

Project description:Adult zebrafish, in contrast to mammals, are able to regenerate their hearts in response to injury or experimental amputation. Our understanding of the cellular and molecular bases that underlie this process, although fragmentary, has increased significantly over the last years. However, the role of the extracellular matrix (ECM) during zebrafish heart regeneration has been comparatively rarely explored. Here, we set out to characterize the ECM protein composition in adult zebrafish hearts, and whether it changed during the regenerative response. For this purpose, we first established a decellularization protocol of adult zebrafish ventricles that significantly enriched the yield of ECM proteins. We then performed proteomic analyses of decellularized control hearts and at different times of regeneration. Our results show a dynamic change in ECM protein composition, most evident at the earliest (7 days post-amputation) time-point analyzed. Regeneration associated with sharp increases in specific ECM proteins, and with an overall decrease in collagens and cytoskeletal proteins. We finally tested by atomic force microscopy that the changes in ECM composition translated to decreased ECM stiffness. Our cumulative results identify changes in the protein composition and mechanical properties of the zebrafish heart ECM during regeneration.

2019-08-26 | PXD010092 | Pride

Characterization of pdgfrb reporter expressing cells from the adult zebrafish heart ventricles by single cell RNA sequencing

Project description:Platelet-derived growth factor (PDGF) signaling regulates perivascular cell or mural cell association with the blood-vessel endothelial cells. Mural cells express the receptor of the signaling, pdgfrb. Besides mural cells the outer epithelial layer of the heart, epicardium and epicardial derived cells express pdgfrb. In this dataset we characterized pdgfrb expressing cells in adult zebrafish heart ventricles in AB wildtype fish, pdgfrb loss-of-function mutant fish. Since pdgfrb is activated in injured zebrafish heart, we aslo compared pdgfrb expressing cells in injured (amputated, 7 days post amputation) heart ventricle with similar cells in uninjured hearts.

2022-02-19 | GSE188511 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data