Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

New viruses detected - results from an early warning system

ABSTRACT: New viruses detected - results from an early warning system - metagenomic screening for unexpected or new viruses

PROVIDER: PRJEB45282 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

New viruses detected - results from an early warning system

Project description:New viruses detected - results from an early warning system - metagenomic screening for unexpected or new viruses

| PRJEB45282 | ENA

Acute lung injury results from innate sensing of viruses by an ER stress pathway

Project description:Incursions of new pathogenic viruses into humans from animal reservoirs are occurring with alarming frequency. The molecular underpinnings of immune recognition, host responses, and pathogenesis in this setting arepoorly understood. We studied pandemic influenza viruses to determine the mechanism by which increasing glycosylation during evolution of surface proteins facilitates diminished pathogenicity in adapted viruses. ER stressduring infection with poorly glycosylated pandemic strains activated the unfolded protein response, leading to inflammation, acute lung injury, and mortality. Seasonal strains or viruses engineered to mimic adapted viruses displaying excess glycans on the hemagglutinin did not cause ER stress, allowing preservation of the lungs and survival. We propose that ER stress resultingfrom recognition of non-adapted viruses is utilized to discriminate “non-self” at the level of protein-processing and to activate immune responses, with unintended consequences on pathogenesis. Understanding this mechanism should improve strategies for treating acute lung injury from zoonotic viral infections. Lung transcription analysis of Influenza A virus infected mice.

2015-07-06 | E-GEOD-65075 | biostudies-arrayexpress

Acute lung injury results from innate sensing of viruses by an ER stress pathway

2015-07-06 | GSE65075 | GEO

New filamentous viruses from the Naldaviricetes class

Project description:This study aims to study new genomes of filamentous viruses forming a new viral family among the Naldaviricetes

| PRJEB62786 | ENA

Pseudomonas aeruginosa phiKZ-like viruses

Project description:New Pseudomonas aeruginosa phiKZ-like viruses

| PRJEB45750 | ENA

dsDNA Filamentous Naldaviricetes viruses

Project description:Six new filamentous viruses from the Naldaviricetes class

| PRJNA964713 | ENA