Project description:This dataset investigates the transcriptional effect of mitochondrial 12S rRNA hypermethylation, both by overexpressing the mitochondrial methyltransferase mtTFB1 in HeLa cells and by using A1555G cybrids, where the 12S rRNA is hypermethylated. HeLa cells overexpressing a methyltransferase-deficient mtTFB1 (mtTFB1[G65A]) and wild-type A1555A cybrids were used as controls. four samples with 12S rRNA hypermethylation (two cell lines, with two biological replicates each) versus four samples with basal 12S rRNA methylation (two cell lines, with two biological replicates each)

2012-09-18 | E-GEOD-33780 | biostudies-arrayexpress

Mitochondrial 12S hypermethylation in HeLa cells and A1555G cybrids

2012-09-18 | GSE33780 | GEO

Mitochondrial 12S rRNA gene sequences from spraint DNA of various Eurasian otters (Lutra lutra)

Project description:Mitochondrial 12S rRNA gene sequences from spraint DNA of various Eurasian otters (Lutra lutra) Targeted loci environmental

| PRJNA548047 | ENA

Mitochondrial 12S rRNA gene sequences amplified without blocking oligonucleotide from spraint DNA of various Eurasian otters (Lutra lutra)

Project description:Mitochondrial 12S rRNA gene sequences amplified without OBS1 from spraint DNA of various Eurasian otters (Lutra lutra)

| PRJNA565647 | ENA

Electrophoresis-Correlative Data-Independent Acquisition (Eco-DIA) Improves the Sensitivity of Mass Spectrometry for Limited Proteome Amounts

Project description:In this project, we developed electrophoresis-correlative (Eco) data-independent acquisition (DIA) mass spectrometry (MS). We recognized a correlation between the measured mass-to-charge (m/z) and migration time (MT) for peptides during capillary electrophoresis (CE) electrospray ionization (ESI) MS. We leveraged this relationship to dynamically tailor the experimental settings of DIA on an orbitrap mass spectrometer. This approach substantially improved utilization of the limited duty cycle during tandem MS and detection sensitivity compared to the classical DIA. From 1 ng of the standard HeLa proteome digest, Eco-DIA identified ~38% more proteins than conventional DIA, without the assistance of a project-specific spectral library. Proteins that were quantified exclusively by Eco-DIA were in the lower abundance range. Eco-DIA improved the sensitivity of detection from limited amounts of proteomes using CE-ESI-MS.

2024-09-17 | PXD051717 | Pride

Bacterial 16S rRNA coding sequences and Eukaryotic 18S rRNA coding sequences

Project description:Bacterial 16S rRNA coding sequences and Eukaryotic 18S rRNA coding sequences Raw sequence reads

| PRJNA587984 | ENA

A Phase I Study of ECO-4601 in Patients With Advanced Cancer

Project description:The purpose of this study was to determine the maximum tolerated dose (MTD) and the recommended dose for future studies of ECO-4601 administered as a continuous IV infusion for 14 days with 7 days recovery (21 day cycle) in patients with histologically confirmed solid tumors (high grade glioma, colorectal, lung, breast, ovarian, pancreatic and prostate). This study was also designed to determine the clinical pharmacokinetic profile, safety of multiple cycles of administration, and document the antitumor activity of ECO-4601.

| 2029824 | ecrin-mdr-crc

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data