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Complete dosage compensation and sex-biased gene expression in Manduca sexta

ABSTRACT: Complete dosage compensation and sex-biased gene expression in Manduca sexta

PROVIDER: PRJEB4959 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	ERR368949.fastq.gz	Fastqsanger.gz
	ERR368950.fastq.gz	Fastqsanger.gz
	ERR368951.fastq.gz	Fastqsanger.gz
	ERR368952.fastq.gz	Fastqsanger.gz
	ERR368953.fastq.gz	Fastqsanger.gz

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Complete dosage compensation and sex-biased gene expression in Manduca sexta

Project description:Using 4 replicate males and 4 replicate females this experiment examined dosage compensation and sex-biased gene expression. Briefly we performed a de novo assembly of the Manduca sexta transcriptome using all sequenced libraries, quantified genes expression, identified the physical locations of genes through orthology to the moth Bombyx mori and examine expression differences between autosomal and Z-linked genes between males and females. Further, we examined sex-biased gene expression using the replicated data.

2014-03-18 | E-MTAB-2066 | biostudies-arrayexpress

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Complete dosage compensation and sex-biased gene expression in the moth Manduca sexta.

Project description:Sex chromosome dosage compensation balances homogametic sex chromosome expression with autosomal expression in the heterogametic sex, leading to sex chromosome expression parity between the sexes. If compensation is incomplete, this can lead to expression imbalance and sex-biased gene expression. Recent work has uncovered an intriguing and variable pattern of dosage compensation across species that includes a lack of complete dosage compensation in ZW species compared with XY species. This has led to the hypothesis that ZW species do not require complete compensation or that complete compensation would negatively affect their fitness. To date, only one study, a study of the moth Bombyx mori, has discovered evidence for complete dosage compensation in a ZW species. We examined another moth species, Manduca sexta, using high-throughput sequencing to survey gene expression in the head tissue of males and females. We found dosage compensation to be complete in M. sexta with average expression between the Z chromosome in males and females being equal. When genes expressed at very low levels are removed by filtering, we found that average autosome expression was highly similar to average Z expression, suggesting that the majority of genes in M. sexta are completely dosage compensated. Further, this compensation was accompanied by sex-specific gene expression associated with important sexually dimorphic traits. We suggest that complete dosage compensation in ZW species might be more common than previously appreciated and linked to additional selective processes, such as sexual selection. More ZW and lepidopteran species should now be examined in a phylogenetic framework, to understand the evolution of dosage compensation.

| S-EPMC3971586 | biostudies-literature

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