Project description:We sequenced mRNA of adult males and females of Daphnia galeata from two clonal lineages (9 days old). Females had no eggs in their brood pouches to minimize expression from embryos and males were naturally produced without the addition of hormones or stressors.

2016-08-15 | E-MTAB-4981 | biostudies-arrayexpress

Population transcriptomics in Daphnia galeata

Project description:Population transcriptomics in Daphnia galeata

| PRJEB23352 | ENA

RNA-seq to investigate the effect of long term exposure to fish kairomones on gene expression in Daphnia galeata

Project description:Two Daphnia galeata clones showing very contrasting responses to fish kairomones were analysed in an RNAseq setup.

2019-01-31 | E-MTAB-6234 | biostudies-arrayexpress

Project description:Tumor-host interactions play an important role in cancer initiation and progression. To investigate changes in local host factors associated with proximity to the tumor, the global gene expression profiles of cancer tissues and histologically normal tissues taken at various distances from the tumor (1 cm, 5 cm and the proximal end of the resected sample) from 32 rectal cancer patients were used to establish a distance-related model. Two distance-related expression patterns were considered, one with a trend toward gradual down-regulation and one with a trend toward gradual up-regulation as the distance from the tumor decreased. Gene Ontology (GO) analysis highlighted 7 genes enriched in the endosomal sorting complex required for transport (ESCRT) machinery in the group with a pattern of gradual down-regulation. Survival analysis of patients in the TCGA colorectal cancer (CRC) dataset revealed that higher expression of two of these genes (PDCD6IP and CHMP2B) was associated with a better prognosis (p = 0.021, p = 0.031). A tissue array confirmed that patients with up-regulated PDCD6IP expression in cancer tissue compared with normal tissue had better prognoses (p = 0.04). In conclusion, we built a distance-related model to study the local tumor-host interactions and identified PDCD6IP as a local host protective factor in CRC.

2017-11-01 | GSE90627 | GEO

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