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Multiomic (Joint snRNA/snATAC) sequencing data of intestinal crypts and epithelial only organoids derived from human fetal duodenum

ABSTRACT: Multiomic (Joint snRNA/snATAC) sequencing data of intestinal crypts and epithelial only organoids derived from human fetal duodenum

PROVIDER: PRJEB54103 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	ERR9917691_1.fastq.gz	Fastqsanger.gz
	ERR9917691_2.fastq.gz	Fastqsanger.gz
	ERR9917686_1.fastq.gz	Fastqsanger.gz
	ERR9917686_2.fastq.gz	Fastqsanger.gz

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Multiomic (Joint snRNA/snATAC) sequencing data of intestinal crypts and epithelial only organoids derived from human fetal duodenum

Project description:Here, we used joint single-nuclei RNA-sequencing (snRNA-seq) and single-nuclei ATAC sequencing (scATAC) to profile freshly isolated crypts from the human fetal intestine and matched intestinal epithelial only organoids (also known as enteroids) derived from these crypts after one passage of in vitro growth. Organoids were grown in the standard 25% LWRN media with either 100 ng/ml of EGF or 1 ng/ml of EREG added. Fresh crypts were not placed in culture but rather immediately frozen for multiomic processing.

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