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Homo sapiens

ABSTRACT: FOXF2-regulated genes in human primary prostate stromal cells

OTHER RELATED OMICS DATASETS IN: E-GEOD-12444

PROVIDER: PRJNA112999 | ENA |

REPOSITORIES: ENA

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FOXF2-regulated genes in human primary prostate stromal cells

2008-11-01 | GSE12444 | GEO

siRNA profiling of human primary prostate stromal cells knocked down for FOXF2

Project description:To identify the genes and pathways regulated by FOXF2, we investigated potential FOXF2 gene targets by microarray analyses of primary prostate stromal cells (PrSC) in which FOXF2 was knocked down by siRNA. 190 differentially expressed genes were selected, of which 104 genes were more highly expressed in PrSC cells treated with FOXF2 siRNA and 86 were more highly expressed in PRSC cells treated with negative control siRNA. Experiment Overall Design: In each experiment, we compared gene expression of PrSC cells treated with FOXF2 siRNA versus PrSC cells treated with negative control siRNA, in a total of 6 affymetrix arrays. 190 differentially expressed genes were selected (ratio negative control siRNA/siRNA â¥ 2log |0.8| as average in all arrays).

2008-11-13 | E-GEOD-12444 | biostudies-arrayexpress

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Project description:siRNA profiling of human primary prostate stromal cells knocked down for FOXF2

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Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity

Project description:We performed single cell RNA-Seq of FACS-isolated CD45+ leukocytes and Lin-CD24- prostate stromal cells from Col1a2-TRAMP(Control) group and Col1a2-Foxf2-TRAMP group. Unsupervised clustering analysis on integrated single-cell datasets revealed an increased CD8+ T cell frequency and activity and a decreased Macrophage and MDSC activity in the Col1a2-Foxf2-TRAMP mice. The analysis in TRAMP mice revealed two major subpopulations that represented the myofibroblastic CAF (myCAF) and inflammatory CAF (iCAF). The percentage of myCAF increased by 15% in the Col1a2-Foxf2-TRAMP mice, suggesting that Foxf2 induced a shift toward the myCAF phenotype. On the other hand, the overall CAF gene signature score defined by the average expression of 30 CAF-associated genes on a single cell level was slightly but significantly reduced in the Col1a2-Foxf2-TRAMP mice.

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