Ornithorhynchus anatinus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA12885 | ENA |
REPOSITORIES: ENA
Similar Datasets
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Project description:Melatonin is a neurohormone produced in both animals and plants. It binds at least three G-protein-coupled receptors: MT1 and MT2, and Mel1cGPR. Mammalian GPR50 evolved from the reptilian/avian Mel1c and lost its capacity to bind melatonin in all the therian mammal species that have been tested. In order to determine if binding is lost in the oldest surviving mammalian lineage of monotremes we investigated whether the melatonin receptor has the ability to bind melatonin in the platypus (Ornithorhynchus anatinus), and evaluated its pharmacological profile. Sequence and phylogenetic analysis showed that platypus has in fact retained the ancestral Mel1c and has the capacity to bind melatonin similar to other mammalian melatonin receptors (MT1 and MT2), with an affinity in the 1 nM range. We also investigated the binding of a set of melatoninergic ligands used previously to characterize the molecular pharmacology of the melatonin receptors from sheep, rats, mice, and humans and found that the general profiles of these compounds make Mel1c resemble human MT1 more than MT2. This work shows that the loss of GPR50 binding evolved after the divergence of monotremes less than 190MYA in therian mammals.
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Project description:Ornithorhynchus anatinus Genome sequencing
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Project description:Targeted genome sequencing of Ornithorhynchus anatinus
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Project description:Ornithorhynchus anatinus Genome sequencing and assembly
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Project description:The mitochondrial genome of the duck-billed platypus has been sequenced
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Project description:Ornithorhynchus anatinus, or duck-billed platypus, is a primitive egg-laying mammal
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Project description:Knowledge of the life-history and population dynamics of Australia's iconic and evolutionarily distinct platypus (Ornithorhynchus anatinus) remains poor. We marked-recaptured 812 unique platypuses (total 1,622 captures), over four decades (1973-2014) in the Shoalhaven River, Australia. Strong sex-age differences were observed in life-history, including morphology and longevity. Apparent survival of adult females (??=?0.76) were higher than adult males (??=?0.57), as in juveniles: females ??=?0.27, males ??=?0.13. Females were highly likely to remain in the same pool (adult: P?=?0.85, juvenile: P?=?0.88), while residency rates were lower for males (adult: P?=?0.74, juvenile: P?=?0.46). We combined survival, movement and life-histories to develop population viability models and test the impact of a range of life-history parameters. While using estimated apparent survival produced unviable populations (mean population growth rate r?=?-0.23, extinction within 20 years), considering residency rates to adjust survival estimates, indicated more stable populations (r?=?0.004, p?=?0.04 of 100-year extinction). Further sensitivity analyses highlighted adult female survival and overall success of dispersal as most affecting viability. Findings provide robust life-history and viability estimates for a difficult study species. These could support developing large-scale population dynamics models required to underpin a much needed national risk assessment for the platypus, already declining in parts of its current distribution.
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Project description:Single-nucleus RNA sequencing (snRNA-seq) was used to profile the transcriptome of 6,751 nuclei in platypus adult testis. This dataset includes two samples from two different individuals. This dataset is part of a larger evolutionary study of adult testis at the single-nucleus level (97,521 single-nuclei in total) across mammals including 10 representatives of the three main mammalian lineages: human, chimpanzee, bonobo, gorilla, gibbon, rhesus macaque, marmoset, mouse (placental mammals); grey short-tailed opossum (marsupials); and platypus (egg-laying monotremes). Corresponding data were generated for a bird (red junglefowl, the progenitor of domestic chicken), to be used as an evolutionary outgroup.
2021-11-08 | E-MTAB-11070 | biostudies-arrayexpress