Mus musculus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA170107 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Tumor antigen specific CD8 Tissue Resident Memory (Trm) Cells
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Project description:Tissue resident memory (Trm) represent a newly described memory T cell population. We have previously characterized a population of Trm that persists within the brain following acute virus infection. Although capable of providing marked protection against a subsequent local challenge, brain Trm do not undergo recall expansion following dissociation from the tissue. Furthermore, these Trm do not depend on the same survival factors as the circulating memory T cell pool as assessed either in vivo or in vitro. To gain greater insight into this population of cells we compared the gene-expression profiles of Trm isolated from the brain to circulating memory T cells isolated from the spleen following an acute virus infection. Trm displayed altered expression of genes involved in chemotaxis, expressed a distinct set of transcription factors and overexpressed several inhibitory receptors. Cumulatively, these data indicates that Trm are a distinct memory T cell population disconnected from the circulating memory T cell pool and displaying a unique molecular signature which likely results in optimal survival and function within their local environment. 13 samples were analyzed: 5 replicates of memory OT-I CD8+.CD103- T cells isolated from the spleen of mice on day 20 p.i. with VSV-OVA. 5 replicates of memory OT-I CD8+CD103+ T cells isolated from the brain of mice on day 20 p.i. with VSV-OVA; and 3 replicates of memory OT-I.CD8+ CD103- T cells isolated from the brain of mice on day 20 p.i. with VSV-OVA
2012-08-29 | E-GEOD-39152 | biostudies-arrayexpress
Project description:Development pathway for skin resident memory CD103+CD8+ T cells
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Project description:Tumor antigen specific CD8 Tissue Resident Memory (Trm) Cells
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Project description:Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells
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Project description:Genome wide transcriptome analysis of skin harboring tissue-resident memory CD8+ T cells
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Project description:Distinguishing innate memory CD8+ T from homeostatically expanded CD8+ T cells
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Project description:Peripherally-induced brain tissue resident memory CD8 T cells [RNA-seq]
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