Project description:Reticuloendotheliosis virus (REV), a member of the Gammaretrovirus genus in the Retroviridae family, causes an immunosuppressive, oncogenic and runting-stunting syndrome in multiple avian hosts. To better understand the host interactions at the transcriptional level, microarray data analysis was performed in chicken embryo fibroblast (CEF) cells at 1, 3, 5, and 7 days after infection with REV. This study identified numerous differentially expressed genes that were classified into several functional groups. Significant differences were mainly observed in the expression of genes involved in the immune response, especially during the later post-infection time points. These results revealed that differentially expressed genes play important roles in the pathogenicity of REV infection. Our study is the first to use microarray analysis to investigate REV, and these findings provide insights into the underlying mechanisms of the host antiviral response and the molecular basis of viral pathogenesis.

2015-02-27 | GSE66320 | GEO

Comparative analysis of rice plants infected with Rice tungro bacilliform virus

Project description:Rice tungro bacilliform virus (RTBV) is determinant of the rice tungro disease symptom. We compare the gene responses by RTBV infection between RTBV susceptive (TN1) and resistant cultivar (TW16). TN1 infected with RTBV shows the mild stunting and leaf yellowing, although TW16 shows only mild stunting at only early infection stage, and recovers the symptoms. Keywords: virus infection, disease response Comparison between RTBV and mock infected rice. Biological replicates: 3 control, 3 infected, independently grown and harvested. 1 samples derived from 5 plants grown under same conditons

2012-12-31 | E-GEOD-38150 | biostudies-arrayexpress

Transcriptional profiling of host gene expression in chicken embryo fibroblasts infected with Reticuloendotheliosis virus strain HA1101

2015-02-27 | E-GEOD-66320 | biostudies-arrayexpress