Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression (part 1)

ABSTRACT: Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression (part 1)

PROVIDER: PRJNA218868 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression (part 2)

Project description:Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression (part 2)

| PRJNA218869 | ENA

Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression (part 2)

Project description:To better characterize how variation in regulatory sequences drives divergence in gene expression, we undertook a systematic study of transcription factor binding and gene expression in blastoderm embryos of four species, which sample much of the diversity in the 40 million-year old genus Drosophila: D. melanogaster, D. yakuba, D. pseudoobscura and D. virilis. We compared gene expression, measured by mRNA-seq, to the genome-wide binding, measured by ChIP-seq, of four transcription factors involved in early anterior-posterior patterning. We found that mRNA levels are much better conserved than individual transcription factor binding events, and that changes in a gene’s expression were poorly explained by changes in adjacent transcription factor binding. However highly bound sites, sites in regions bound by multiple factors and sites near genes are conserved more frequently than other binding, suggesting that a considerable amount of transcription factor binding is weakly or non-functional and not subject to purifying selection

2013-09-12 | GSE50771 | GEO

Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression

Project description:Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression

| PRJNA218867 | ENA

Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression (part 1)

Project description:We sequenced mRNA from blastoderm embryos of Drosophila melanogaster, Drosophila yakuba, Drosophila pseudoobscura and Drosophila virilis. Two samples contain pooled mRNA from several species, and the remaining 24 samples contain mRNA from a single species. Methods: Retinal mRNA profiles of Blastoderm embryos

2013-09-12 | GSE50766 | GEO

Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression (part 1)

2013-09-12 | E-GEOD-50766 | biostudies-arrayexpress

Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression.

Project description:To better characterize how variation in regulatory sequences drives divergence in gene expression, we undertook a systematic study of transcription factor binding and gene expression in blastoderm embryos of four species, which sample much of the diversity in the 40 million-year old genus Drosophila: D. melanogaster, D. yakuba, D. pseudoobscura and D. virilis. We compared gene expression, measured by mRNA-seq, to the genome-wide binding, measured by ChIP-seq, of four transcription factors involved in early anterior-posterior patterning. We found that mRNA levels are much better conserved than individual transcription factor binding events, and that changes in a gene's expression were poorly explained by changes in adjacent transcription factor binding. However, highly bound sites, sites in regions bound by multiple factors and sites near genes are conserved more frequently than other binding, suggesting that a considerable amount of transcription factor binding is weakly or non-functional and not subject to purifying selection.

| S-EPMC3772039 | biostudies-literature

Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-09-12 | E-GEOD-50773 | biostudies-arrayexpress

Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-09-12 | GSE50773 | GEO

Regulatory divergence during pig limb evolution

Project description:Genome-wide comparative analyses of the open chromatin profiles between equivalent stages of mouse and pig limb bud development reveal the extensive functional divergence of their limb regulomes. These alterations affect evolutionary conserved regions located in the genomic landscapes of genes with essential functions during limb development. This analysis uncovers the widespread regulatory changes that appear to underlie the morphological diversion of the artiodactyl limb from the pentadactyl blueprint of tetrapods.

2020-03-31 | GSE126291 | GEO

Regulatory divergence during mouse limb evolution

2020-03-31 | GSE126292 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data