Resource for Genetic Epidemiology Research in Adult Health and Aging (“GERA”)
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA226739 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium is a collaborative effort which aims to conduct genome-wide meta-analyses of various phenotypes.
| EGAO00000000011 | EGA
Project description:Genetics Resource with the Health and Retirement Study
| PRJNA80263 | ENA
Project description:Resource for Genetic Epidemiology Research in Adult Health and Aging (“GERA”)
| PRJNA226740 | ENA
Project description:NHLBI SNP Health Association Resource (SHARe) Projects, genome-wide association studies in NHLBI cohorts
| PRJNA51455 | ENA
Project description:This study is part of the Mutant Mouse Regional Resource Center Research. The series subsets represent the strain and age group for easy comparisons. Each subseries has data for three different tissues (brain, liver and kidney) and 2 sexes. Keywords: other
2005-10-18 | E-GEOD-1920 | biostudies-arrayexpress
Project description:This study is part of the Mutant Mouse Regional Resource Center Research. The series subsets represent the strain and age group for easy comparisons. Each subseries has data for three different tissues (brain, liver and kidney) and 2 sexes. Keywords: other
2005-10-18 | GSE1920 | GEO
Project description:Diminishment of colonic health is associated with various age-related pathologies. Calorie restriction (CR) is an efficient strategy to increase healthy lifespan, although underlying mechanisms are not fully elucidated. Here we report the effects of lifelong CR on markers of colonic health in aging mice. We show that 30% energy reduction, as compared to a control (C) and moderate-fat (MF) diet, is associated with attenuated immune-related gene expression and lower levels of bile acids in the colon. Pronounced shifts in microbiota composition, together with lowered plasma levels of interleukin 6, in mice exposed to CR are in line with these findings. Furthermore, expression of genes involved in lipid metabolism was higher upon CR as compared to C and MF, pointing towards efficient regulation of energy metabolism. Switching from CR to an ad libitum MF diet at old age revealed remarkable phenotypic plasticity, although expression of a small subset of genes remained CR-associated. This research demonstrates that CR beneficially affects markers of colonic health in aging mice and as such may attenuate the progressive age-related decline in health.
2018-03-27 | GSE100701 | GEO
Project description:Bazi Bushen (BZBS), a traditional Chinese medicine, has been proven effective for the treatment in age-related disease models. However, its role in health improvement during the aging process has not yet been explored. In the present study, we investigated the anti-aging effect of BZBS in nature aging mice through Frailty Index assessment, liver DNA methylome, and epigenetic age estimation. Highly differentiated DNA methylation was presented between the young and aged mice, which was mainly concentrated in the promoter region. BZBS treatment protected mice from age-associated DNA methylation changes so that rejuvenated epigenetic age. This result was consistent with the phenotypic observations, including enhanced memory and muscle endurance, less liver lesions, and lower frailty score. Aging-related database screen together with KEGG analysis suggested that methylation-targeted genes upon BZBS treatment were involved in several essential pathways including oxidation-reduction processes, genome stability, MAPK signaling, and inflammation. Up regulation of key effectors in Sirt3-Foxo1 and DNA repair signaling were confirmed. Finally, in silico analysis of the formula revealed anti-aging properties of Renshen, Shengdihuang, Yinyanghuo, and Gouqizi, as well as their potential methylation-regulatory functions. In sum, our work reports the first anti-aging effects of Traditional Chinese Medicine via epigenetic mechanism, thus providing potential life prolonging opportunities.
2023-02-27 | GSE215310 | GEO
Project description:The decrease in the podocyte’s lifespan and health-span that typify healthy kidney aging cause a decrease in their normal structure, physiology and function. The ability to halt and even reverse these changes becomes clinically relevant when disease is superimposed on an aged kidney. RNA-sequencing of podocytes from middle-aged mice showed an inflammatory phenotype with increases in the NLRP3 inflammasome, signaling for IL2/Stat5, IL6 and TNF, interferon gamma response, allograft rejection and complement, consistent with inflammaging. Furthermore, injury-induced NLRP3 signaling in podocytes was further augmented in aged mice compared to young ones. The NLRP3 inflammasome (NLRP3, Caspase-1, IL1ß IL-18) was also increased in podocytes of middle-aged humans. Higher transcript expression for NLRP3 in human glomerular was accompanied by reduced podocyte density and increased global glomerulosclerosis and glomerular volume. Pharmacological inhibition of NLRP3 with MCC950, or gene deletion, reduced podocyte senescence and the genes typifying aging in middle-aged mice, which was accompanied by an improved podocyte lifespan and health-span. Moreover, modeling the injury-dependent increase in NLRP3 signaling in human kidney organoids confirmed the anti-senescence effect of MC9950. Finally, the impact of NLRP3 also impacted liver aging. Together, these results suggest a critical role for the NLRP3 inflammasome in podocyte and liver aging.
2023-08-01 | GSE226796 | GEO
Project description:The Kaiser Permanente (KP) Research Program on Genes, Environment and Health (RPGEH), in collaboration with the University of California-San Francisco, undertook genome-wide genotyping of >100,000 subjects that constitute the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. The project, which generated >70 billion genotypes, represents the first large-scale use of the Affymetrix Axiom Genotyping Solution. Because genotyping took place over a short 14-month period, creating a near-real-time analysis pipeline for experimental assay quality control and final optimized analyses was critical. Because of the multi-ethnic nature of the cohort, four different ethnic-specific arrays were employed to enhance genome-wide coverage. All assays were performed on DNA extracted from saliva samples. To improve sample call rates and significantly increase genotype concordance, we partitioned the cohort into disjoint packages of plates with similar assay contexts. Using strict QC criteria, the overall genotyping success rate was 103,067 of 109,837 samples assayed (93.8%), with a range of 92.1-95.4% for the four different arrays. Similarly, the SNP genotyping success rate ranged from 98.1 to 99.4% across the four arrays, the variation depending mostly on how many SNPs were included as single copy vs. double copy on a particular array. The high quality and large scale of genotype data created on this cohort, in conjunction with comprehensive longitudinal data from the KP electronic health records of participants, will enable a broad range of highly powered genome-wide association studies on a diversity of traits and conditions.
| S-EPMC4574249 | biostudies-literature