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Staphylococcus aureus

ABSTRACT: Mode of action analysis: Distinct Staphylococcus aureus transcriptome changes upon antivirulence hydroxy amide treatment

PROVIDER: PRJNA271787 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1744480.fastq.gz	Fastqsanger.gz
	SRR1744481.fastq.gz	Fastqsanger.gz
	SRR1744482.fastq.gz	Fastqsanger.gz
	SRR1744483.fastq.gz	Fastqsanger.gz
	SRR1744484.fastq.gz	Fastqsanger.gz

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MULTI-TARGETED FLAVONOID INHIBITION OF THE PATHOGENIC BACTERIUM STAPHYLOCOCCUS AUREUS: A Proteomic Characterization

Project description:Growth inhibition of the pathogen Staphylococcus aureus with currently available antibiotics is problematic in part due to bacterial biofilm protection. While Although the recently characterized natural products, including 3´,4´,5-trihydroxy-6,7-dimethoxy-flavone [1], 3´,4´,5,6,7-pentahydroxy-flavone [2] and 5-hydroxy-4´,7-dimethoxy-flavone [3] exhibit both antibiotic and biofilm inhibitory activities, the mode of action of such hydroxylated flavonoids with respect to S. aureus inhibition has is yet to be characterized. Enzymatic digestion and high- resolution MS mass spectral analysis of differentially expressed proteins from S. aureus, with and without exposure to antibiotic flavonoids (1-3) has allowed for the characterization of global -protein alterations induced by metabolite treatment. A total of 56, 92, and 110 proteins are were differentially expressed with bacterial exposure to 1, 2 or 3, respectively. Connectivity of identified proteins is characterized using a search tool for the retrieval of interacting genes/proteins (STRING) with multi-targeted S. aureus inhibition of energy metabolism and biosynthesis by the assayed flavonoids observed. Identifying the mode of action of natural products as antibacterial agents is expected to provide insight into the potential use of flavonoids alone or in combination with known therapeutic agents to effectively control S. aureus infection.

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Antimicrobial activity of graphene oxide is associated with alteration in stress response and membrane proteins

Project description:The aim of this study was to explore the mode of action of GO, via an in-depth proteomics analysis, on the protein expression of targeted bacteria. For this purpose, samples of Staphylococcus aureus were grown in the presence of GO and samples were collected from different growth phases to examine cell viability and to analyze the changes in protein expression.

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