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Plasmodium berghei ANKA

ABSTRACT: Global Transcriptional Repression: Initial and Essential Step for Plasmodium Sexual Development [ChIP-seq]

PROVIDER: PRJNA276082 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1813460.fastq.gz	Fastqsanger.gz
	SRR1813461.fastq.gz	Fastqsanger.gz
	SRR1813462.fastq.gz	Fastqsanger.gz
	SRR1813463.fastq.gz	Fastqsanger.gz

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Neuropilin-1+ vs. Neuropilin-1- CD8+ T cells from Plasmodium berghei ANKA-infected mice

Project description:Characterization of Neuropilin-1+ and Neuropilin-1- splenic CD8+ T cells from Plasmodium berghei ANKA-infected C57BL/6 mice

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Global Transcriptional Repression: Initial and Essential Step for Plasmodium Sexual Development [ChIP-seq]

Project description:Gametocytes are nonreplicative sexual forms that mediate malaria transmission to a mosquito vector. They are generated from asexual blood stage parasites, which proliferate in the circulation. However, it remains largely unknown as to how this transition is genetically regulated. Here, we report that an Apetala2 (AP2) family transcription factor, AP2-G2, regulates the transition as a transcriptional repressor. Disruption of AP2-G2 in the rodent malaria parasites, Plasmodium berghei, did not prevent commitment to the sexual stage but halted their development before manifesting sex-specific morphologies. ChIP-seq analysis revealed that AP2-G2 targets approximately 1,500 genes and recognizes a five-base motif on their promoters. Most of these target genes are required for asexual proliferation in the blood by the parasites, thereby suggesting that AP2-G2 blocks the program for asexual replication of parasites in the blood. DNA microarray analysis showed that the identified targets constituted approximately 70% of the upregulated genes in AP2-G2-depleted parasites, and a promoter assay using a centromere plasmid demonstrated that the binding motif functions as a cis-acting negative regulatory element. These results suggest that global transcriptional repression, which occurs during the initial phase of gametocytogenesis, is an essential step to promote conversion to the sexual stage.

2015-10-01 | GSE66189 | GEO

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