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Staphylococcus aureus subsp. aureus NCTC 8325

ABSTRACT: Staphylococcus aureus subsp. aureus NCTC 8325 Raw sequence reads

PROVIDER: PRJNA279231 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1926311_1.fastq.gz	Fastqsanger.gz
	SRR1926311_2.fastq.gz	Fastqsanger.gz
	SRR1926312_1.fastq.gz	Fastqsanger.gz
	SRR1926312_2.fastq.gz	Fastqsanger.gz
	SRR1926313_1.fastq.gz	Fastqsanger.gz

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Predictive characterization of hypothetical proteins in Staphylococcus aureus NCTC 8325.

Project description:Staphylococcus aureus is one of the most common hospital acquired infections. It colonizes immunocompromised patients and with the number of antibiotic resistant strains increasing, medicine needs new treatment options. Understanding more about the proteins this organism uses would further this goal. Hypothetical proteins are sequences thought to encode a functional protein but for which little to no evidence of that function exists. About half of the genomic proteins in reference strain S. aureus NCTC 8325 are hypothetical. Since annotation of these proteins can lead to new therapeutic targets, a high demand to characterize hypothetical proteins is present. This work examines 35 hypothetical proteins from the chromosome of S. aureus NCTC 8325. Examination includes physiochemical characterization; sequence homology; structural homology; domain recognition; structure modeling; active site depiction; predicted protein-protein interactions; protein-chemical interactions; protein localization; protein stability; and protein solubility. The examination revealed some hypothetical proteins related to virulent domains and protein-protein interactions including superoxide dismutase, O-antigen, bacterial ferric iron reductase and siderophore synthesis. Yet other hypothetical proteins appear to be metabolic or transport proteins including ABC transporters, major facilitator superfamily, S-adenosylmethionine decarboxylase, and GTPases. Progress evaluating some hypothetical proteins, particularly the smaller ones, was incomplete due to limited homology and structural information in public repositories. These data characterizing hypothetical proteins will contribute to the scientific understanding of S. aureus by identifying potential drug targets and aiding in future drug discovery.

| S-EPMC5267966 | biostudies-literature

Staphylococcus aureus subsp. aureus NCTC 8325

Project description:Transcriptome analysis of the eukaryotic-type ser/thr kinase PknB in Staphylococcus aureus

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Staphylococcus aureus subsp. aureus NCTC 8325

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Staphylococcus aureus subsp. aureus NCTC 8325

Project description:The nucleoid occlusion factor Noc controls DNA replication initiation in Staphylococcus aureus [Tn-seq]

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Project description:Effect of SAOUHSC_02810 deletion in S. aureus NCTC8325

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Global transcriptional profiling of Staphylococcus aureus treated with rhein

Project description:Staphylococcus aureus is one of the most important pathogens in humans and animals, multiply resistant strains are increasingly widespread, new agents are needed for the treatment of S. aureus. Rhein, a natural plant product, has potential antimicrobial activity against Staphylococcus aureus. We employed Affymetrix Staphylococcus aureus GeneChipsTM arrays to investigate the global transcriptional profiling of Staphylococcus aureus ATCC25923 treated with rhein. Results provided insight into mechanisms involved in rhein - Staphylococcus aureus interactions. Keywords: rhein response

2007-06-15 | GSE8135 | GEO

Staphylococcus aureus subsp. aureus NCTC 8325

Project description:Effect of TetR family regulator SAOUHSC_02897 deletion in S. aureus NCTC8325

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Global transcriptional profiling of Staphylococcus aureus treated with magnolol

Project description:Staphylococcus aureus (S. aureus) is an important human and animal pathogen, multiply resistant strains are increasingly widespread, new agents are needed for the treatment of S. aureus. magnolol has potent antimicrobial activity against S. aureus. We employed Affymetrix Staphylococcus aureus GeneChipsTM arrays to investigate the global transcriptional profiling of Staphylococcus aureus ATCC25923 treated with magnolol. Keywords: gene expression array-based, count

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Global transcriptional profiling of Staphylococcus aureus treated with eugenol

Project description:Staphylococcus aureus (S. aureus) is an important human and animal pathogen, multiply resistant strains are increasingly widespread, new agents are needed for the treatment of S. aureus. eugenol, a natural plant product, has potent antimicrobial activity against S. aureus. We employed Affymetrix Staphylococcus aureus GeneChipsTM arrays to investigate the global transcriptional profiling of Staphylococcus aureus ATCC25923 treated with eugenol. Keywords: gene expression array-based, count

2007-08-10 | GSE8735 | GEO

Global transcriptional profiling of Staphylococcus aureus treated with cryptotanshinone

Project description:Staphylococcus aureus (S. aureus) is an important human and animal pathogen, multiply resistant strains are increasingly widespread, new agents are needed for the treatment of S. aureus. Cryptotanshinone, a natural plant product, has potent antimicrobial activity against S. aureus. We employed Affymetrix Staphylococcus aureus GeneChipsTM arrays to investigate the global transcriptional profiling of Staphylococcus aureus ATCC25923 treated with cryptotanshinone. Keywords: gene expression array-based, count

2008-10-16 | GSE13203 | GEO

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