Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Oral-nasopharyngeal metagenome

ABSTRACT: Nasal microbiome of dogs

PROVIDER: PRJNA319381 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR4453490.fastq.gz	Fastqsanger.gz
	SRR4453500.fastq.gz	Fastqsanger.gz
	SRR4453510.fastq.gz	Fastqsanger.gz
	SRR4453520.fastq.gz	Fastqsanger.gz
	SRR4453530.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 49

Similar Datasets

oral-nasopharyngeal metagenome

Project description:Nasal microbiome of cats

| PRJNA319380 | ENA

oral-nasopharyngeal metagenome

Project description:Canine nasal and oral microbiome

| PRJNA314694 | ENA

oral-nasopharyngeal metagenome

Project description:Mice sino nasal microbiome Targeted Locus (Loci)

| PRJNA295682 | ENA

oral-nasopharyngeal metagenome

Project description:Canine oral and nasal microbiome Targeted Locus (Loci)

| PRJNA287803 | ENA

Host-Microbe Interactions in the Nasal Cavity of Dogs with Chronic Idiopathic Rhinitis

Project description:Chronic rhinitis (CR) is a frustrating clinical syndrome in dogs and our understanding of the disease pathogenesis in is limited. Increasingly, host-microbe interactions are considered key drivers of clinical disease in sites of persistent mucosal inflammation such as the nasal and oral cavities. Therefore, we applied next generation sequencing tools to interrogate abnormalities present in the nose of dogs with CR and compared immune and microbiome profiles to those of healthy dogs. Host nasal cell transcriptomes were evaluated by RNA sequencing, while microbial communities were assessed by 16S rRNA sequencing. Correlation analysis was then used to identify significant interactions between nasal cell transcriptomes and the nasal microbiome and how these interactions were altered in animals with CR. Notably, we observed significant downregulation of multiple genes associated with ciliary function in dogs with CR, suggesting a previously undetected role for ciliary dysfunction in this syndrome. We also found significant upregulation of immune genes related to the TNF-a and interferon pathways. The nasal microbiome was also significantly altered in CR dogs, with overrepresentation of several potential pathobionts. Interactome analysis revealed significant correlations between bacteria in the genus Porphyromonas and the upregulated host inflammatory responses in dogs with CR, as well as defective ciliary function which was correlated with Streptococcus abundance. These findings provide new insights into host-microbe interactions in a canine model of CR and indicate the presence of potentially causal relationships between nasal pathobionts and the development of nasal inflammation and ciliary dysfunction.

2024-08-08 | GSE255529 | GEO

human nasopharyngeal metagenome

Project description:Nasal microbiome of colonized, non-colonized, and infected neonates in NICU

| PRJNA741227 | ENA

Gene expression in canine sino-nasal aspergillosis and idiopathic lymphoplasmacytic rhinitis

Project description:Analyse of gene expression profiling in nasal mucosa of dogs affected by sino-nasal aspergillosis or lymphoplasmacytic rhinitis.

2012-01-01 | E-MEXP-3166 | biostudies-arrayexpress

human nasopharyngeal metagenome

Project description:human nasal/pharyngeal metagenome

| PRJNA338893 | ENA

human nasopharyngeal metagenome

Project description:Nasal and Oral Metagenome Metagenome

| PRJNA392433 | ENA

oral metagenome

Project description:Metagenome of oral cavity of dogs

| PRJNA836950 | ENA