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SETBP1-WT and SETBP1-G870S epigenetic landscapes

ABSTRACT: SETBP1-WT and SETBP1-G870S epigenetic landscapes

PROVIDER: PRJNA341463 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR4113520_1.fastq.gz	Fastqsanger.gz
	SRR4113520_2.fastq.gz	Fastqsanger.gz
	SRR4113530_1.fastq.gz	Fastqsanger.gz
	SRR4113530_2.fastq.gz	Fastqsanger.gz
	SRR4113521_1.fastq.gz	Fastqsanger.gz

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SETBP1-WT and SETBP1-G870S epigenetic landscapes

Project description:SETBP1-WT and SETBP1-G870S epigenetic landscapes

| PRJNA341463 | ENA

SETBP1-WT and SETBP1-G870S transcriptional profiles [RNA-Seq]

Project description:RNA-Seq experiments on SETBP1-G870S and Empty cells was performed in order to assess if the presence of mutated SETBP1 may induce differential RNA expression.

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SETBP1-WT and SETBP1-G870S epigenetic landscapes [ChIP-Seq]

Project description:ChIP-Seq experiments targeting H3K4me2, H3K4me3, H3K9ac, H3K27ac, H3K36me3 histone modifications have been performed in order to assess if SETBP1 binding to gDNA was associated with chromatin remodeling and to further characterize the mechanisms responsible for SETBP1-mediated transcriptional regulation

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Homo sapiens

Project description:SETBP1-WT and SETBP1-G870S epigenetic landscapes [ChIP-Seq]

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SETBP1-WT and SETBP1-G870S DNA binding propensity [ChIP-Seq TF]

Project description:ChIP-seq against V5 has been performed in order to investigate the role of SETBP1 as a DNA binding protein

2017-09-01 | GSE86334 | GEO

SETBP1-WT and SETBP1-G870S epigenetic landscapes

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-09-01 | GSE86335 | GEO

Homo sapiens

Project description:SETBP1-WT and SETBP1-G870S transcriptional profiles [RNA-Seq]

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Transcriptional regulation by SETBP1 and SETBP1(D/N) in mouse hematopoietic stem and progenitor cells

Project description:Global gene expression changes induced by Setbp1 and Setbp1(D/N) in purified mouse hematopoietic stem and progenitor cells were characterized by RNA-seq analysis; ChIP-seq studies to identify cooperation between SETBP1/SETBP1(D/N) and MLL1 in regulating gene transcription in hematopoietic stem and progenitor cells.

2021-12-17 | GSE167301 | GEO

Homo sapiens

Project description:SETBP1-WT and SETBP1-G870S DNA binding propensity [ChIP-Seq TF]

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Effect of DNMT3A R882H mutation or WT expression on epigenetic landscapes of hematopoietic stem/progenitor cells with NRAS G12D co-transduction (ChIP-seq)

Project description:DNA Methyltransferase 3A (DNMT3A) is frequently mutated in various hematopoietic malignancies; however, the underlying oncogenic mechanisms remain elusive. Here, we report that DNMT3A mutational âhotspotâ at Arg882 (DNMT3A-R882H) cooperates with constitutively activated RAS in transforming murine hematopoietic stem/progenitor cells (HSPCs) ex vivo and inducing acute leukemias in vivo. DNMT3A-R882H potentiates aberrant transactivation of âstemnessâ gene expression programs, notably transcription factors Meis1, Hox-A, Mn1 and Mycn. Mechanistically, R882-mutated DNMT3A directly binds to cis-regulatory elements of these genes and induces focal CpG hypomethylation reminiscent of what was seen in human leukemias bearing DNMT3A R882 mutation. Furthermore, DNMT3A-R882H induced DNA hypomethylation facilitates gene enhancer/promoter activation and recruitment of Dot1l-associated transcription elongation machineries. Inactivation of Dot1l represses DNMT3AR882H-mediated stem cell gene dysregulation and acute leukemogenicity. In this dataset, we provided H3K4me1, H3K27ac and H3K79me2 ChIP-seq profiling data showing effect of DNMT3A R882H mutation or WT expression on epigenetic landscapes of hematopoietic stem/progenitor cells with NRAS G12D co-transduction. ChIP-seq analysis of Lin- enriched hematopoietic stem/progenitor cells with retroviral infection of NRAS G12D alone (EV-RAS), DNMT3A R882H with NRAS G12D (RH-RAS) or DNMT3A WT with NRAS G12D (WT-RAS) 3 weeks post-transduction. Antibodies of H3K4me1, H3K27ac and H3K79me2 were used.

2016-06-23 | E-GEOD-71472 | biostudies-arrayexpress

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