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Homo sapiens

ABSTRACT: Genes regulated by SPDEF or FOXA3 in A549 lung carcinoma cells [RNA-seq]

PROVIDER: PRJNA343086 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR4244290.fastq.gz	Fastqsanger.gz
	SRR4244291.fastq.gz	Fastqsanger.gz
	SRR4244292.fastq.gz	Fastqsanger.gz
	SRR4244293.fastq.gz	Fastqsanger.gz
	SRR4244294.fastq.gz	Fastqsanger.gz

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Genes regulated by SPDEF or FOXA3 in A549 lung carcinoma cells [RNA-seq]

Project description:To identify genes regulated by SPDEF or FOXA3 in A549 lung carcinoma cells, we analyzed the whole-transcriptomic mRNA profiles of A549 cells expressing SPDEF or FOXA3 based on RNA-seq.

2017-03-02 | GSE86956 | GEO

Homo sapiens

Project description:Genes regulated by SPDEF or FOXA3 in A549 lung carcinoma cells [RNA-seq]

| PRJNA343086 | ENA

Genome-wide mapping of NKX2-1 and SPDEF binding sites in A549 lung carcinoma cells by ChIP-seq

Project description:ChIP-seq was performed to identify the binding regions of SPDEF and NKX2-1 in A549 lung carcinoma cells expressing NKX2-1 and SPDEF.

2017-03-02 | GSE86957 | GEO

Homo sapiens

Project description:Genome-wide mapping of NKX2-1 and SPDEF binding sites in A549 lung carcinoma cells by ChIP-seq

| PRJNA343085 | ENA

Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death

Project description:Background: Lung cancer is the leading cause of cancer related death worldwide. Over the past 15 years no major improvement of survival rates could be accomplished. The recently discovered histone methyltransferase KMT9 as epigenetic regulator of prostate tumor growth has now raised hopes of enabling new cancer therapies. In this study we aimed to identify the function of KMT9 in lung cancer which has remained elusive so far. Methods: We linked full transcriptome and proteome analyses of A549 lung adenocarcinoma cells using RNA-Seq and mass spectrometry with functional cell culture, real-time proliferation and flow cytometry assays. Results: KMT9 is expressed in lung cancer tissue and cell lineswith high levels of KMT9 correlating with poor patient survival. We identified 460 overlapping genes and proteins that are deregulated upon knock-down of KMT9alpha in A549 cells. These genes cluster with proliferation, cell cycle and cell death gene sets as well as with subcellular organelles in gene ontology analysis. Knock-down of KMT9alpha inhibits lung cancer cell proliferation and induces non-apoptotic cell death in A549 cells. Conclusions: The novel histone methyltransferase KMT9 is crucial for proliferation and survival of lung cancer cells harboring various mutations. Small molecule inhibitors targeting KMT9 therefore should be further examined as potential milestones in modern epigenetic lung cancer therapy.

2020-05-26 | PXD014145 | Pride

Homo sapiens

Project description:Profiling of genes regulated by TGF-beta in lung carcinoma (A549) and immortalized lung epithelial (HPL1D)cells.

| PRJNA97963 | ENA

Nrf2 regulated genes in A549 cells

Project description:Nrf2 regulated genes in A549 cells

| PRJNA451429 | ENA

Genome-wide gene expression analysis for CRISPRi targeting a human SFTPB locus bound by NKX2-1

Project description:RNA-seq was performed to identify genes affected by CRISPRi (dCas9-KRAB) with sgRNA (sgSFTPB#2) targeting the first intronic region of human SFTPB bound by NKX2-1 in an unbiased genome-wide fashion using A549 lung carcinoma cells that constitutively express dCas9-KRAB and NKX2-1.

2021-03-25 | GSE162186 | GEO

Homo sapiens

Project description:Analysis of Nkx2-1-regulated gene expression in A549 lung carcinoma cells

| PRJNA174347 | ENA

RNA sequencing of in vitro generated suppressive myeloid cells using parental and Sialidase expressing A549 cancer cell lines

Project description:Fresh peripheral blood mononuclear cells of four human donors were cultured together with either lung adenocarcinoma A549 cancer cells or A549-expressing H1N1 Sialidase cancer cells. These treatments induced the differentiation of donor cells into immunosuppressive MDSC-like cells, which were further subjected to bulk RNA sequencing. Computational analysis of RNA-Seq profiles of these cells was applied to understand the differences in their suppressive capacities.

| EGAS00001007618 | EGA

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