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CTCF translates IL-2- and aKG-sensitive metabolic changes in T cells into context-dependent differentiation gene programs

ABSTRACT: CTCF translates IL-2- and aKG-sensitive metabolic changes in T cells into context-dependent differentiation gene programs

PROVIDER: PRJNA353354 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5015950_1.fastq.gz	Fastqsanger.gz
	SRR5015950_2.fastq.gz	Fastqsanger.gz
	SRR5015960_1.fastq.gz	Fastqsanger.gz
	SRR5015960_2.fastq.gz	Fastqsanger.gz
	SRR5016350.fastq.gz	Fastqsanger.gz

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CTCF translates IL-2- and αKG-sensitive metabolic changes in T cells into context-dependent differentiation gene programs [HiC-Seq]

Project description:We found that aspects of the IL-2-sensitive effector gene program in CD4+ Th1 and CD8+ Tc1 cells are regulated by glutamine and alpha-ketoglutarate (αKG)-induced events, in part through changes in DNA and histone methylation states. We further identified a novel mechanism by which IL-2- and αKG-sensitive metabolic changes regulate the association of CTCF with select genomic sites. αKG-sensitive CTCF sites were often associated with loci containing IL-2- and αKG-sensitive genome organization patterns and gene expression in T cells. Surprisingly, IL-2- and αKG-sensitive CTCF sites in T cells were also associated with genes from developmental pathways that had αKG-sensitive expression in ES cells. The data collectively support a novel mechanism wherein CTCF serves to translate αKG-sensitive metabolic changes into context-dependent differentiation gene programs.

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CTCF translates IL-2- and aKG-sensitive metabolic changes in T cells into context-dependent differentiation gene programs

Project description:This SuperSeries is composed of the SubSeries listed below.

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