Project description:To investigate the effect of CAMKV inhibitor, OTSSP167, on NB cell proliferation and delineate the mechanisms of CAMKV-mediated pathway inhibition in NB. We treated human neuroblastoma cell line, NGP with OTSSP167 and performed gene expression profiling analysis using data obtained from RNA-seq.
Project description:To investigate the effect of ERK inhibitor, ulixertinib, on NB cell proliferation and delineate the mechanisms of ulixertinib-mediated ERK pathway inhibition in NB. We treated human neuroblastoma cell line, NGP with ulixertinib and performed gene expression profiling analysis using data obtained from RNA-seq.
Project description:CUT&RUN sequencing to define binding sites for SOX11 and IgG in the neuroblastoma cell lines IMR-32, CLB-GA and NGP as well as neuroblastoma cell line SH-EP after SOX11 overexpression for 48h. A SOX11 inducible overexpression system was generated using a Tet-on system.
