Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA356171 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR5074730.fastq.gz | Fastqsanger.gz | |||
| SRR5074740.fastq.gz | Fastqsanger.gz | |||
| SRR5074750.fastq.gz | Fastqsanger.gz | |||
| SRR5074760.fastq.gz | Fastqsanger.gz | |||
| SRR5074770_1.fastq.gz | Fastqsanger.gz |
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Project description:Adult tissue stem cells (SCs) reside in niches, which through intercellular contacts and signaling, influence SC behavior. Once activated, SCs typically give rise to short-lived transit-amplifying cells (TACs), which then progress to differentiate into their lineages. Here, using single cell RNA-sequencing, we unearth unexpected heterogeneity among SCs and TACs of hair follicles. We trace the roots of this heterogeneity to micro-niches along epithelial-mesenchymal interfaces, where progenitors display molecular signatures reflective of spatially distinct local signals and intercellular interactions. Using lineage-tracing, temporal single cell analyses and chromatin landscaping, we show that SC plasticity becomes restricted in a sequentially and spatially choreographed program, culminating in seven spatially arranged uni-lineage progenitors within TACs of mature follicles. By compartmentalizing SCs into micro-niches, tissues gain precise control over morphogenesis and regeneration: Some progenitors specify lineages immediately; others retain potency, preserving self-renewing features established early while progressively restricting lineages as they experience dynamic changes in microenvironment.
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Project description:This SuperSeries is composed of the SubSeries listed below.
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