Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gut microbiome

ABSTRACT: wild and captive gut Raw sequence reads

PROVIDER: PRJNA358755 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5149820.fastq.gz	Fastqsanger.gz
	SRR5149830.fastq.gz	Fastqsanger.gz
	SRR5149840.fastq.gz	Fastqsanger.gz
	SRR5149850.fastq.gz	Fastqsanger.gz
	SRR5149860.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 218

Similar Datasets

gut microbiome

Project description:gut microbiome Raw sequence reads

| PRJNA608183 | ENA

gut microbiome

Project description:chicken gut microbiome Raw sequence reads

| PRJNA747156 | ENA

human gut microbiome

Project description:human gut microbiome Raw sequence reads

| PRJNA564945 | ENA

Human Gut Microbiome

Project description:Human Gut Microbiome Raw sequence reads

| PRJNA804374 | ENA

Human gut microbiome

Project description:Human gut microbiome Raw sequence reads

| PRJNA608678 | ENA

Quail gut microbiome

Project description:Quail gut microbiome Raw sequence reads

| PRJNA419264 | ENA

Human gut microbiome

Project description:Human gut microbiome Raw sequence reads

| PRJNA645402 | ENA

mouse gut microbiome

Project description:mouse gut microbiome Raw sequence reads

| PRJNA548724 | ENA

Morus alba Raw protein sequence reads

Project description:Morus alba L. Raw protein sequence reads and sequence

2024-02-08 | PXD049451 |

Morphine treatment induces distinct changes in the gut microbiome at day 3 post treatment

Project description:Opioids such as morphine have many beneficial properties as analgesics, however, opioids may induce multiple adverse gastrointestinal symptoms. We have recently demonstrated that morphine treatment results in significant disruption in gut barrier function leading to increased translocation of gut commensal bacteria. However, it is unclear how opioids modulate the gut homeostasis. By using a mouse model of morphine treatment, we studied effects of morphine treatment on gut microbiome. We characterized phylogenetic profiles of gut microbes, and found a significant shift in the gut microbiome and increase of pathogenic bacteria following morphine treatment when compared to placebo. In the present study, wild type mice (C57BL/6J) were implanted with placebo, morphine pellets subcutaneously. Fecal matter were taken for bacterial 16s rDNA sequencing analysis at day 3 post treatment. A scatter plot based on an unweighted UniFrac distance matrics obtained from the sequences at OTU level with 97% similarity showed a distinct clustering of the community composition between the morphine and placebo treated groups. By using the chao1 index to evaluate alpha diversity (that is diversity within a group) and using unweighted UniFrac distance to evaluate beta diversity (that is diversity between groups, comparing microbial community based on compositional structures), we found that morphine treatment results in a significant decrease in alpha diversity and shift in fecal microbiome at day 3 post treatment compared to placebo treatment. Taxonomical analysis showed that morphine treatment results in a significant increase of potential pathogenic bacteria. Our study shed light on effects of morphine on the gut microbiome, and its role in the gut homeostasis.

2018-04-16 | E-MTAB-5546 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data