Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human-specific features of special gene expression and regulation in eight brain regions

ABSTRACT: Human-specific features of special gene expression and regulation in eight brain regions

PROVIDER: PRJNA393104 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5804420_1.fastq.gz	Fastqsanger.gz
	SRR5804420_2.fastq.gz	Fastqsanger.gz
	SRR5804430_1.fastq.gz	Fastqsanger.gz
	SRR5804430_2.fastq.gz	Fastqsanger.gz
	SRR5804440_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 214

Similar Datasets

Human-specific features of special gene expression and regulation in eight brain regions

Project description:Despite the substantial efforts made to compile the molecular maps of the human brain, they do not fully inform us of the features unique to humans. Yet, identification of these features might help us to understand both the evolution and nature of the human cognitive traits. Here, we approached this question by analyzing gene expression and H3K27ac chromatin modification data collected in eight brain regions of humans, chimpanzees, gorillas, gibbon and macaques. Integrated analysis of these data revealed existence of 1,851 human-specific transcriptome differences affecting one or multiple brain regions, in contrast to 240 chimpanzee-specific ones. More than a half of these differences represented elevated expression in human hippocampus, while the rest affected microglial functions in neocortex. Analysis of predicted regulatory interactions driving these differences revealed role of transcription factors in species-specific transcriptome changes, while epigenetic modifications were linked to spatial expression differences conserved across species.

2018-06-04 | GSE100796 | GEO

Human-specific features of spatial gene expression and regulation in eight brain regions.

Project description:Molecular maps of the human brain alone do not inform us of the features unique to humans. Yet, the identification of these features is important for understanding both the evolution and nature of human cognition. Here, we approached this question by analyzing gene expression and H3K27ac chromatin modification data collected in eight brain regions of humans, chimpanzees, gorillas, a gibbon, and macaques. An analysis of spatial transcriptome trajectories across eight brain regions in four primate species revealed 1851 genes showing human-specific transcriptome differences in one or multiple brain regions, in contrast to 240 chimpanzee-specific differences. More than half of these human-specific differences represented elevated expression of genes enriched in neuronal and astrocytic markers in the human hippocampus, whereas the rest were enriched in microglial markers and displayed human-specific expression in several frontal cortical regions and the cerebellum. An analysis of the predicted regulatory interactions driving these differences revealed the role of transcription factors in species-specific transcriptome changes, and epigenetic modifications were linked to spatial expression differences conserved across species.

| S-EPMC6071643 | biostudies-literature

eight coral species

Project description:eight coral species Transcriptome or Gene expression

| PRJNA377358 | ENA

Methylation profiling of human bladder cancer cell lines to identify methylation features in promoter regions

Project description:To identify methylation features in the promoter regions of genes in bladder cancer.

2008-01-22 | E-MTAB-2 | biostudies-arrayexpress

NIA/NIH AGEMAP Brain Regions

Project description:NIA/NIH AGEMAP Brain Regions

| PRJNA101483 | ENA

Towards a human brain EV atlas: Characteristics of EVs from different brain regions, including small RNA and protein profiles

Project description:Brain derived EVs (bdEVs) from eight brain regions, including orbitofrontal gyrus(ORB), postcentral gyrus (POSTC), hippocampus (HIPPO), thalamus (THAL), occipital gyrus (OCC), medulla (MED), corpus callosum (CORP), and cerebellum (CBLM) were separated and characterized by small RNA sequencing. We aim to provide an atlas of bdEV molecular profiles with brain region specificity.

2023-08-07 | GSE226490 | GEO

Transcriptome analyses reveal enrichment of specific lncRNAs in specific brain regions and neuronal populations

Project description:Despite the availability of large-scale transcriptomics data, specific long noncoding RNAs (lncRNAs) expressed in specific brain regions and populations of neurons are poorly understood. Here we report analysis of expression of lncRNAs and mRNAs expressed in hippocampus and prefrontal cortex (PFC), two regions of brain that are involved in memory storage and neuropsychiatric disorders. Our unbiased analyses have identified specific lncRNAs and mRNAs that are enriched in hippocampus and PFC. We have identified several regions in the chromosomes characterized by clustered lncRNA expression suggesting the transcriptional hotspots of lncRNA in the genome. We find that, a subset of lncRNAs and protein coding genes in their vicinity are uniquely co-expressed in specific brain regions and thus presumably co-regulated. Furthermore, specific brain regions and neuronal populations have characteristic lncRNA expression profile. These studies reveal unexpected complexity in the expression profiles of lncRNAs in the mammalian brain.

2015-03-06 | GSE61401 | GEO

Eight shrimp farm soil sediment metagenomes

Project description:Eight shrimp farm soil sediment metagenomes

| PRJNA809862 | ENA

Expression data from E17.5 mouse brain regions

Project description:Expression data from E17.5 mouse brain regions

| PRJNA590834 | ENA

Gene expression variation among eight maize inbreds

Project description:Expression profiling analyses for eight maize inbreds reveals extensive transcriptional variation. Many genes exhibit presence-absence variation among the inbred lines. Keywords: Genotype comparison series

2008-01-26 | GSE10237 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data