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Homo sapiens

ABSTRACT: Differential expression of microRNAs in productively HIV-1 infected and bystander macrophages in culture.

PROVIDER: PRJNA401712 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5998750.fastq.gz	Fastqsanger.gz
	SRR5998751.fastq.gz	Fastqsanger.gz
	SRR5998752.fastq.gz	Fastqsanger.gz
	SRR5998744.fastq.gz	Fastqsanger.gz
	SRR5998745.fastq.gz	Fastqsanger.gz

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Differential expression of microRNAs in productively HIV-1 infected and bystander macrophages in culture.

Project description:Macrophages are heterogeneous immune cells with distinct origins, phenotypes, functions and tissue localization. Their susceptibility to HIV-1 is subject to variations from permissiveness to resistance, owing in part to regulatory microRNAs. Here, we used RNAseq to examine the expression of >400 microRNAs in productively infected and bystander cells of HIV-1-exposed macrophage cultures. Two micro-RNAs up regulated in bystander macrophages, miR-221 and miR-222, were identified as negative regulators of CD4 expression and CD4-mediated HIV-1 entry. Both microRNAs were enhanced by TNF-α, an inhibitor of CD4 expression. MiR-221/miR-222 inhibitors recovered HIV-1 entry in TNF-α-treated macrophages by enhancing CD4 expression, and increased HIV-1 replication and spread in macrophages by countering TNF-α-enhanced miR-221/miR-222 expression in bystander cells. In line with these findings, HIV-1-resistant intestinal myeloid cells express higher levels of miR-221 than peripheral blood monocytes. Thus, miR-221/miR-222 act as effectors of the antiviral host response activated during macrophage infection that restrict HIV-1 entry.

2017-09-11 | GSE103394 | GEO

Global mapping of the macrophage-HIV-1 transcriptome reveals that productive infection induces remodeling of the host cell DNA and chromatin

Project description:It has been proposed that macrophages could serve as long-lived compartments for HIV-1 infection under in vivo situations because these cells are resistant to the virus-mediated cytopathic effect, produce progeny virus over extended periods of time and are localized in tissues that are often less accessible by treatment. Comprehensive experimental studies are thus needed to characterize the HIV-1-induced modulation of host genes in these myeloid lineage cells. To shed light on this important issue, we performed comparative analyses of mRNA expression levels of host genes in uninfected bystander and HIV-1-infected human macrophages using an infectious reporter virus construct coupled with a large-scale RNA sequencing approach. We observed a rapid differential expression of several host factors in the productively infected macrophage population including genes regulating DNA replication factors and chromatin remodeling. A siRNA-mediated screening study to functionally identify host determinants involved in HIV-1 biology has provided new information on the virus molecular regulation in macrophages.

2021-07-21 | GSE180273 | GEO

Homo sapiens

Project description:Differential Gene Expression in HIV-Infected Individuals Following ART.

| PRJNA189206 | ENA

Homo sapiens

Project description:Expression analysis of microRNAs in plasma of new HIV-infected cases, old HIV-infected cases and healthy controls.

| PRJNA401865 | ENA

Homo sapiens

Project description:Differential gene expression between infected and non-infected dendritic cells with HIV-1

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Homo sapiens whole blood.

Project description:RNA extracted at 240min. Samples are rRNA depleted. Expression measurement of Homo sapiens genes.

2019-07-31 | GSE114179 | GEO

Homo sapiens

Project description:Expression data from IFN alpha 2-treated macrophages infected with HIV

| PRJNA144657 | ENA

Homo sapiens whole blood infected with Candida spp. (here: Candida tropicalis)

Project description:Homo sapiens fresh whole blood was infected with Candida tropicalis. RNA-pool of both species extracted at 0min (control), 15, 30, 60, 120, 240 min. Samples are rRNA depleted. Measurement of Candida tropicalis gene expression.

2019-07-31 | GSE114178 | GEO

Homo sapiens whole blood infected with Candida spp. (here: Candida parapsilosis)

Project description:Homo sapiens fresh whole blood was infected with Candida parapsilosis. RNA-pool of both species extracted at 0min (control), 15, 30, 60, 120, 240 min. Samples are rRNA depleted. Measurement of Homo sapiens gene expression.

2018-12-26 | GSE114177 | GEO

Homo sapiens whole blood infected with Candida spp. (here: Candida glabrata)

Project description:Homo sapiens fresh whole blood was infected with Candida glabrata. RNA-pool of both species extracted at 0min (control), 15, 30, 60, 120, 240 min. Samples are rRNA depleted. Measurement of Candida glabrata gene expression.

2018-12-26 | GSE114175 | GEO

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