Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Caenorhabditis elegans isolate:N2

ABSTRACT: The combinatorial control of alternative splicing in C. elegans

PROVIDER: PRJNA412927 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6129520_1.fastq.gz	Fastqsanger.gz
	SRR6129520_2.fastq.gz	Fastqsanger.gz
	SRR6129521_1.fastq.gz	Fastqsanger.gz
	SRR6129521_2.fastq.gz	Fastqsanger.gz
	SRR6129522_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Caenorhabditis elegans N2: Control vs. Lysinibacillus sphaericus-fed

Project description:Transcriptional profiling of Caenorhabditis elegans comparing control E. coli OP50-fed C. elegans with L. sphaericus-fed C. elegans

2014-04-01 | GSE54682 | GEO

Caenorhabditis elegans

Project description:Genome-wide analysis of alternative splicing in Caenorhabditis elegans

| PRJNA135673 | ENA

CCAR-1 regulates the alternative splicing of multiple genes in Caenorhabditis elegans

Project description:The Cell Division Cycle and Apoptosis Regulator (CCAR) protein family members have recently emerged as regulators of alternative splicing and transcription, as well as having other key physiological functions. For example, mammalian CCAR2/DBC1 forms a complex with the zinc factor protein ZNF326 to integrate alternative splicing with RNA polymerase II transcriptional elongation in AT-rich regions of the DNA. Additionally, Caenorhabditis elegans CCAR-1, a homolog to mammalian CCAR2, facilitates the alternative splicing of the perlecan unc-52 gene. However, much about the CCAR family's role in alternative splicing is unknown. We are interested in uncovering the role of the CCAR family in alternative splicing in vivo using Caenorhabditis elegans. We examined the role of CCAR-1 in genome-wide alternative splicing and identified new alternative splicing targets of CCAR-1 using RNA sequencing. Also, we found that CCAR-1 interacts with the spliceosome factors UAF-1 and UAF-2 using mass spectrometry, and that knockdown of ccar-1 affects alternative splicing patterns, motility, and proteostasis of UAF-1 mutant worms. Collectively, we demonstrate a role for CCAR-1 in the regulation of global alternative splicing in C. elegans and in conjunction with UAF-1

2024-02-26 | PXD043100 | Pride

Caenorhabditis elegans isolate:N2

Project description:Caenorhabditis elegans intestinal transcriptome

| PRJNA291676 | ENA

Caenorhabditis elegans N2: Control vs. Lysinibacillus sphaericus-fed

Project description:Transcriptional profiling of Caenorhabditis elegans comparing control E. coli OP50-fed C. elegans with L. sphaericus-fed C. elegans Two-condition experiment, E. coli OP50-fed C. elegans vs. L. sphaericus-fed C. elegans

2014-04-01 | E-GEOD-54682 | biostudies-arrayexpress

Caenorhabditis elegans

Project description:Global genetic robustness of the alternative splicing machinery in C. elegans

| PRJNA116849 | ENA

Caenorhabditis elegans

Project description:The role of SPK-1 in alternative splicing regulation in C. elegans

| PRJNA255993 | ENA

Caenorhabditis elegans

Project description:Deciphering the C. elegans embryonic transcriptome with tissue, time, and alternative splicing resolution

| PRJNA477006 | ENA

Genome-wide analysis of alternative splicing in Caenorhabditis elegans

Project description:Alternative splicing (AS) plays a crucial role in the diversification of gene function and regulation. Consequently, the systematic identification and characterization of temporally regulated splice variants is of critical importance to understanding animal development. We have used high-throughput RNA sequencing and microarray profiling to analyze AS in C. elegans across various stages of development. This analysis identified thousands of novel splicing events, including hundreds of developmentally regulated AS events. To make these data easily accessible and informative, we constructed the C. elegans Splice Browser, a web resource in which researchers can mine AS events of interest and retrieve information about their relative levels and regulation across development. The data presented in this study, along with the Splice Browser, provides the most comprehensive set of annotated splice variants in C. elegans to date, and is therefore expected to faciliate focused, high resolution in vivo functional assays of AS function. Alternative splicing events were identified from alignments of C. elegans mRNA/EST sequences (UniGene Build #26) to C. elegans genomic sequence (NCBI timestamp: Sept. 25, 2006), essentially as previously described (Pan et al. 2005; Pan et al. 2004). In total, 499 cassette type AS events were identified. For each AS event, 3 exon probes and 3 exon junction probes were designed to profile the AS event on the microarray, essentially as previously described (Pan et al. 2004). This submission represents the expression microarray component of the study.

2010-12-14 | E-GEOD-25927 | biostudies-arrayexpress

Caenorhabditis elegans strain:N2

Project description:Caenorhabditis elegans

| PRJNA268307 | ENA