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Auricularia auricula-judae

ABSTRACT: Auricularia auricula-judae Raw sequence reads

PROVIDER: PRJNA414695 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6188980_1.fastq.gz	Fastqsanger.gz
	SRR6188980_2.fastq.gz	Fastqsanger.gz
	SRR6188981_1.fastq.gz	Fastqsanger.gz
	SRR6188981_2.fastq.gz	Fastqsanger.gz
	SRR6188982_1.fastq.gz	Fastqsanger.gz

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Auricularia auricula-judae

Project description:Auricularia auricula-judae Raw sequence reads

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Auricularia auricula-judae

Project description:Auricularia auricula-judae overview

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Clinical observation of Auricularia auricula-judae in preventing postoperative liver metastasis in patients with stage II-III colorectal cancer

Project description:Interventions: Auricularia auricula-judae diet group:On the basis of normal diet, the total amount of dried Auricularia auricula-judae is 30g per week, which can be divided into 3-4 days to eat, dry Auricularia auricula-judae can be boiled in warm water and added when cooking or cold dishes, or when making porridge and soup.;Auricularia auricula-judae free diet group:Normal diet, diet does not contain black fungus. Primary outcome(s): Liver metastasis recurrence rate Study Design: Parallel

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Auricularia auricula-judae strain:Au916

Project description:Auricularia auricula-judae strain:Au916 Transcriptome or Gene expression

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Auricularia auricula-judae strain:B14-8

Project description:Auricularia auricula-judae strain B14-8 Genome sequencing and assembly

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Auricularia auricula polysaccharides reduce obesity in mice through gut commensal Papillibacter cinnamivorans [liver]

Project description:Auricularia auricula is a well-known traditional edible and medicinal fungus with high nutritional and pharmacological values, as well as metabolic and immunoregulatory properties. However, the exact mechanisms underlying the effects of Auricularia auricula polysaccharides (AAP) on obesity and related metabolic endpoints, including the role of the gut microbiota, remain insufficiently understood. To determine the mechanistic role of the gut microbiota in observed anti-obesogenic effects AAP, faecal microbiota transplantation (FMT) and pseudo germ-free mice model treated with antibiotics were also applied, together with 16S rRNA genomic-derived taxonomic profiling. HFD murine exposure to AAP thwarted weight-gains, reduced fat depositing, together with upregulating thermogenesis proteomic biomarkers within adipose tissue. These effects were associated with diminished intestine/bloodstream-borne lipid transportation, together with enhanced glucose tolerance. FMT administered in tandem with antibiotic treatment demonstrated the intestinal microbiota was necessary in deploying AAP anti-obesogenic functions. Intestine-dwelling microbial population assessments discovered AAP to enhance (in a selective manner) Papillibacter cinnamivorans, a commensal bacterium having reduced presence within HFD mice. Notably, HFD mice treated with oral formulations of Papillibacter cinnamivorans diminished obesity and was linked to decreased intestinal lipid transportation. Datasets from the present study show that AAP thwarted dietary-driven obesity and metabolism-based disorders through regulating intestinal lipid transportation, a mechanism that is dependent on the gut commensal Papillibacter cinnamivorans. These results indicated AAP and Papillibacter cinnamivorans as newly identified pre- and probiotics that could possibly serve as novel countermeasure against obesity.

2022-05-03 | GSE201950 | GEO

Auricularia auricula polysaccharides reduce obesity in mice through gut commensal Papillibacter cinnamivorans [colon]

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Comparative transcriptome analysis reveals relationship of three major domesticated varieties of Auricularia auricula-judae.

Project description:Auricularia auricula-judae is an edible mushroom and a traditional medicine in China as well as the fourth largest cultivated mushroom species in the world. Here for the first time, we present comparative transcriptome analyses of the fruiting bodies of three morphologically distinguishable A. auricula-judae cultivated varieties (Wujin, smooth; Banjin, partially wrinkled; and Quanjin, fully wrinkled) collected from Jilin Province, China. Biological triplicates were performed to determine the expression levels of 13,937 unigenes. Among them, only 13 unigenes were annotated to A. auricula-judae, highlighting the lack of publicly available reference sequences for this economically important species. Principal component analysis (PCA) determined that the gene expression profile of Quanjin was unique when compared to those of Banjin and Wujin. Such relationships were further supported by analyses of annotated and unannotated unigenes, differentially expressed unigenes, gene ontology functions, and the family of peroxidase genes. Using the KEGG database, significant alternations in biological pathways were detected among the three cultivars. This work contributes a large set of A. auricula-judae sequences to public database, establishes the relationships among major cultivars, and provides molecular guidance for breeding and cultivation.

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Project description:Auricularia heimuer Raw sequence reads

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