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Long non-coding RNAs and mRNAs profiling during spleen development in pig

ABSTRACT: Long non-coding RNAs and mRNAs profiling during spleen development in pig

OTHER RELATED OMICS DATASETS IN: GSE106381

PROVIDER: PRJNA416652 | ENA |

REPOSITORIES: ENA

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Long non-coding RNAs and mRNAs profiling during spleen development in pig

Project description:We describe a total 222.19 Gb of pig RNA-seq sequences generated from the 18 libraries

2018-02-16 | GSE106381 | GEO

Long non-coding RNAs and mRNAs profiling during spleen development in pig.

Project description:Genome-wide transcriptomic studies in humans and mice have become extensive and mature. However, a comprehensive and systematic understanding of protein-coding genes and long non-coding RNAs (lncRNAs) expressed during pig spleen development has not been achieved. LncRNAs are known to participate in regulatory networks for an array of biological processes. Here, we constructed 18 RNA libraries from developing fetal pig spleen (55 days before birth), postnatal pig spleens (0, 30, 180 days and 2 years after birth), and the samples from the 2-year-old Wild Boar. A total of 15,040 lncRNA transcripts were identified among these samples. We found that the temporal expression pattern of lncRNAs was more restricted than observed for protein-coding genes. Time-series analysis showed two large modules for protein-coding genes and lncRNAs. The up-regulated module was enriched for genes related to immune and inflammatory function, while the down-regulated module was enriched for cell proliferation processes such as cell division and DNA replication. Co-expression networks indicated the functional relatedness between protein-coding genes and lncRNAs, which were enriched for similar functions over the series of time points examined. We identified numerous differentially expressed protein-coding genes and lncRNAs in all five developmental stages. Notably, ceruloplasmin precursor (CP), a protein-coding gene participating in antioxidant and iron transport processes, was differentially expressed in all stages. This study provides the first catalog of the developing pig spleen, and contributes to a fuller understanding of the molecular mechanisms underpinning mammalian spleen development.

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