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Saccharomyces cerevisiae BY4741

ABSTRACT: Yeast chromosome

PROVIDER: PRJNA427106 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR6417984_1.fastq.gz	Fastqsanger.gz
	SRR6417984_2.fastq.gz	Fastqsanger.gz
	SRR6417985_1.fastq.gz	Fastqsanger.gz
	SRR6417985_2.fastq.gz	Fastqsanger.gz
	SRR6417986_1.fastq.gz	Fastqsanger.gz

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Project description:Aneuploidy and aging are correlated; however, a causal link between these two phenomena has remained elusive. Here we show that yeast disomic for a single native yeast chromosome generally have a decreased replicative lifespan. In addition, the extent of this lifespan deficit correlates with the size of the extra chromosome. We identified a mutation in BUL1 that rescues both the lifespan deficit and a protein trafficking defect in yeast disomic for chromosome 5. Bul1 is an E4 ubiquitin ligase adaptor involved in a protein quality-control pathway that targets membrane proteins for endocytosis and destruction in the lysosomal vacuole thereby maintaining protein homeostasis. Concurrent suppression of the aging and trafficking phenotypes suggests that disrupted membrane protein homeostasis in aneuploid yeast may contribute to their accelerated aging. The data reported here demonstrate that aneuploidy can impair protein homeostasis, shorten lifespan, and may contribute to age-associated phenotypes.

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Saccharomyces cerevisiae BY4741

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Project description:Single-cell RNA-seq reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress

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Project description:Learning the regulatory grammar of yeast 5' untranslated regions from a large library of random sequences

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Effect of the antifungal protein PeAfpA in the expression profile of Saccharomyces cerevisiae BY4741 strain.

Project description:Transcriptomic study to characterize the interaction of the Penicillium expansum antifungal protein PeAfpA with the the model yeast Saccharomyces cerevisiae. For this, the transcriptome of S. cerevisiae BY4741 strain was compared among samples treated with increasing concentrations of PeAfpA.

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