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Small-RNA-Seq in human T-cell lymphoblastic lymphoma samples and control thymuses

ABSTRACT: small-RNA-Seq in human T-cell lymphoblastic lymphoma samples and control thymuses

OTHER RELATED OMICS DATASETS IN: GSE109231GSE109234

PROVIDER: PRJNA430228 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6495850.fastq.gz	Fastqsanger.gz
	SRR6495851.fastq.gz	Fastqsanger.gz
	SRR6495852.fastq.gz	Fastqsanger.gz
	SRR6495853.fastq.gz	Fastqsanger.gz
	SRR6495854.fastq.gz	Fastqsanger.gz

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Human T-cell lymphoblastic lymphoma samples and control thymuses

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small-RNA-Seq in human T-cell lymphoblastic lymphoma samples and control thymuses

Project description:Precursor T-cell lymphoblastic neoplasms are aggressive haematological neoplasm that most often manifest with extensive marrow and blood affectation (T-cell acute lymphoblastic leukaemia or T-ALL) or less commonly as a thymic mass with limited bone marrow infiltration (T-cell lymphoblastic lymphoma or T-LBL). Here we show data from small-RNA-Seq in a sample series of T-LBL from Spanish patients.The goal was to determine the levels of expression of coding genes and microRNAs, and to identify all genetic variants including SNVs, indels, and fusion transcripts.

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RNA-Seq in human T-cell lymphoblastic lymphoma samples and control thymuses

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Project description:Precursor T-cell lymphoblastic neoplasms are aggressive haematological neoplasm that most often manifest with extensive marrow and blood affectation (T-cell acute lymphoblastic leukaemia or T-ALL) or less commonly as a thymic mass with limited bone marrow infiltration (T-cell lymphoblastic lymphoma or T-LBL). Here we show data from RNA-Seq in a sample series of T-LBL from Spanish patients.The goal was to determine the levels of expression of coding genes and microRNAs, and to identify all genetic variants including SNVs, indels, and fusion transcripts.

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Human T-cell lymphoblastic lymphoma samples and control thymuses

Project description:This SuperSeries is composed of the SubSeries listed below.

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Affymetrix SNP array data for acute lymphoblastic leukemia and lymphoblastic lymphoma samples

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Project description:Childhood T-cell malignancies include T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). T-ALL and T-LBL share common morphologic and immunophenotypic features and are treated with similar therapeutic approaches. Nonetheless, they show distinct clinical presentations suggesting that they may represent two different biological entities. In order to investigate the common and unique genetic aberrations of T-LBL and T-ALL, copy number alteration (CNA) analysis was performed on a subset of the samples analyzed by GEP Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from diagnostic bone marrow aspirates or tumor tissue samples. Copy number analysis of Affymetrix 100K SNP arrays was performed for 9 T-ALL and 9 T-LBL pediatric samples. The samples from leukemia/lymphoma remission were used as references for copy number inference.

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