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Involvement of B cells, immunoglobulins, and Syk in the pathogenesis of abdominal aortic aneurysm

ABSTRACT: Involvement of B cells, immunoglobulins, and Syk in the pathogenesis of abdominal aortic aneurysm

PROVIDER: PRJNA431575 | ENA |

REPOSITORIES: ENA

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Involvement of B cells, immunoglobulins, and Syk in the pathogenesis of abdominal aortic aneurysm II

Project description:Background—Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in older individuals. Currently, therapeutic options are limited to surgical interventions. Although it has long been known that AAA tissue is enriched in B cells and immunoglobulins, their involvement in AAA pathogenesis remains controversial. Methods and Results— We investigated the role of B cells and immunoglobulins in a murine model of AAA, induced with a periaortic application of CaCl2, and in human AAA. Both human and mouse AAA tissue showed B cell infiltration. Mouse AAA tissue showed deposition of IgG and activation of Syk, a key molecule in B cell activation and immunoglobulin function, which were localized to infiltrating cells including B cells and macrophages. B cell-deficient muMT mice showed suppression of AAA development that was associated with reduced activation of Syk and less expression of Mmp9. Administration of exogenous immunoglobulins restored the blunted Syk activation and AAA development in muMT mice. Additionally, exogenous immunoglobulins induced IL-6 and MMP9 secretions in human AAA tissue cultures. Furthermore, administration of R788, a specific Syk inhibitor, suppressed AAA expansion, reduced inflammatory response, and reduced immunoglobulin deposition in AAA tissue. Conclusions—From these results, we concluded that B cells and immunoglobulins participated in AAA pathogenesis by promoting inflammatory and tissue destructive activities. Finally, we identified Syk as a potential therapeutic target.

2018-04-25 | GSE109639 | GEO

Involvement of B cells, immunoglobulins, and Syk in the pathogenesis of abdominal aortic aneurysm I

2018-04-25 | GSE109638 | GEO

Involvement of B cells, immunoglobulins, and Syk in the pathogenesis of abdominal aortic aneurysm I

Project description:Involvement of B cells, immunoglobulins, and Syk in the pathogenesis of abdominal aortic aneurysm I

| PRJNA431589 | ENA

Involvement of B cells, immunoglobulins, and Syk in the pathogenesis of abdominal aortic aneurysm II

Project description:Involvement of B cells, immunoglobulins, and Syk in the pathogenesis of abdominal aortic aneurysm II

| PRJNA431588 | ENA

RNA-sequencing of abdominal aortic aneurysm (AAA) and control abdominal aorta tissues

Project description:Abdominal aortic aneurysm (AAA) is a permanent segmental dilatation of the abdominal aorta, contributing to a high mortality once rupture. We performed RNA-sequencing analysis of abdominal aorta tissues from 14 participants, including seven patients with AAA and seven control individuals.

2023-12-07 | GSE183464 | GEO

Involvement of B cells, immunoglobulins, and Syk in the pathogenesis of abdominal aortic aneurysm

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-04-25 | GSE109640 | GEO

Involvement of B Cells, Immunoglobulins, and Syk in the Pathogenesis of Abdominal Aortic Aneurysm.

Project description:BACKGROUND:Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in older individuals. Currently, therapeutic options are limited to surgical interventions. Although it has long been known that AAA tissue is enriched in B cells and immunoglobulins, their involvement in AAA pathogenesis remains controversial. METHODS AND RESULTS:We investigated the role of B cells and immunoglobulins in a murine model of AAA, induced with a periaortic application of CaCl2, and in human AAA. Both human and mouse AAA tissue showed B-cell infiltration. Mouse AAA tissue showed deposition of IgG and activation of Syk, a key molecule in B-cell activation and immunoglobulin function, which were localized to infiltrating cells including B cells and macrophages. B-cell-deficient muMT mice showed suppression of AAA development that was associated with reduced activation of Syk and less expression of matrix metalloproteinase-9. Administration of exogenous immunoglobulins restored the blunted Syk activation and AAA development in muMT mice. Additionally, exogenous immunoglobulins induced interleukin-6 and metalloproteinase-9 secretions in human AAA tissue cultures. Furthermore, administration of R788, a specific Syk inhibitor, suppressed AAA expansion, reduced inflammatory response, and reduced immunoglobulin deposition in AAA tissue. CONCLUSIONS:From these results, we concluded that B cells and immunoglobulins participated in AAA pathogenesis by promoting inflammatory and tissue-destructive activities. Finally, we identified Syk as a potential therapeutic target.

| S-EPMC5907549 | biostudies-literature

RNA Sequencing Analysis of Intracranial Aneurysm Walls Reveals Involvement of Lysosomes and Immunoglobulins in Rupture

Project description:RNA Sequencing Analysis of Intracranial Aneurysm Walls Reveals Involvement of Lysosomes and Immunoglobulins in Rupture

| PRJNA506840 | ENA

Circular RNA expression profiles in human abdominal aortic aneurysm

Project description:We have employed circRNA microarray expression profiling as a discovery platform to identify the dysregulated circRNAs in human abdominal aortic aneurysm.

2020-02-18 | GSE144431 | GEO

Gene expression changes in human thoracic and abdominal aortic aneurysm tissue

Project description:To determine how gene expression is altered in aorta tissue in response to aortic aneurysm disease. Thoracic or abdominal aorta tissue was isolated from patients requiring surgery due to aortic aneurysm or other (control) reason.

2024-10-09 | GSE202267 | GEO

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