Project description:Strain differences in gene expression in the hypothalamus of BXD recombinant inbred mice We used microarrays to evaluate genetic and sex-specific differences in gene expression in the hypothalamus Hypothalamus was dissected from adult male and female mice and process for expression analysis

2012-03-22 | E-GEOD-36674 | biostudies-arrayexpress

Profiling of hypothalamus tissue from the F2 M16xICR mouse cross.

Project description:We profiled gene expression in hypothalamus tissue from F2 progeny from a cross between the outbred M16 (selectively bred for rapid weight gain) and ICR (control) mouse strains. We developed a framework for reconstructing tissue-to-tissue coexpression networks between genes in hypothalamus, liver or hypothalamus tissues that are independent of networks constructed from single tissue analyses. The subnetworks we identify as specific to tissue-to-tissue interactions associate with multiple obesity-relevant biological functions like circadian rhythm, energy balance, stress response, or immune response. Keywords: Tissue profiling in a mouse F2 cross. We analyzed 308 hypothalamus samples.

2010-06-22 | E-GEOD-13745 | biostudies-arrayexpress

Profiling of hypothalamus tissue from the F2 M16xICR mouse cross.

2009-10-26 | GSE13745 | GEO

Hypothalamus proteomics from mouse models with obesity and anorexia reveals novel therapeutic targets of appetite regulation

Project description:This study examined the proteomic profile of hypothalamus in mouse models of obesity and anorexia

2016-03-11 | PXD003475 | Pride

Expression data of hypothalamus from the BACHD and HTT overexpression mouse models of Huntington's disease (HD)

Project description:We used microarrays to investigate whether transcriptional dysregulation in hypothalamus is caused by expression of the huntingtin (HTT) protein We used two different Huntington's disease mouse models: BACHD mice with ubiquitous full-length mutant HTT expression (97 CAG repeats) and wild-type mice with targeted bilateral injections of wild-type or mutant HTT (853 amino acids length, wild-type HTT: 18 CAG repeats, mutant HTT: 79 CAG repeats) in hypothalamus.

2022-10-18 | GSE215217 | GEO

Transcriptomics of Glp1r-expressing cells in mouse hypothalamus tissue

Project description:We purified Glp1r-expressing cells from mouse hypothalamus by FACS and identified cell types distinguished by transcripts.

2022-04-27 | GSE199216 | GEO

Transcriptomics of Rxfp4-expressing cells in mouse hypothalamus tissue

Project description:We purified Rxfp4-expressing cells from mouse hypothalamus by FACS and identified cell types distinguished by transcripts.

2022-11-21 | GSE178897 | GEO

Genome-wide analysis of fasting induced gene expression in the mouse hypothalamus

Project description:Genome-wide analysis of fasting induced gene expression in the mouse hypothalamus

| PRJNA578637 | ENA