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Medial prefrontal cortex (mPFC) transcriptome analysis of Shank3-overexpressing mice

ABSTRACT: Medial prefrontal cortex (mPFC) transcriptome analysis of Shank3-overexpressing mice

PROVIDER: PRJNA450933 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7039082_1.fastq.gz	Fastqsanger.gz
	SRR7039082_2.fastq.gz	Fastqsanger.gz
	SRR7039083_1.fastq.gz	Fastqsanger.gz
	SRR7039083_2.fastq.gz	Fastqsanger.gz
	SRR7039084_1.fastq.gz	Fastqsanger.gz

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Medial prefrontal cortex (mPFC) transcriptome analysis of Shank3-overexpressing mice

Project description:Shank3 is a core excitatory postsynaptic protein expressed in multiple brain regions including the medial prefrontal cortex, striatum, and hippocampus. We have previously generated and characterized Shank3-overexpressing transgenic mice, and found that these mice exhibited manic-like behavioral phenotypes. To understand molecular mechanisms underlying the behavioral changes, we performed transcriptome (RNA-sequencing) analysis of the mPFC tissues from 10 to 12-week-old wild-type and Shank3 transgenic mice.

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