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SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [ATAC-seq]

ABSTRACT: SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [ATAC-seq]

PROVIDER: PRJNA470678 | ENA |

REPOSITORIES: ENA

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SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds

Project description:SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds

| PRJNA470673 | ENA

SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [ChIP-seq]

Project description:SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [ChIP-seq]

| PRJNA470681 | ENA

SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [RNA-seq]

Project description:SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [RNA-seq]

| PRJNA470680 | ENA

SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [ATAC-seq]

Project description:This study describes the functions of SMAD4 during early mouse limb bud development by identifying the direct transcriptional targets

2021-07-29 | GSE114255 | GEO

SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [ChIP-seq]

Project description:This study describes the functions of SMAD4 during early mouse limb bud development by identifying the direct transcriptional targets

2021-07-29 | GSE114253 | GEO

SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds [RNA-seq]

Project description:This study describes the functions of SMAD4 during early mouse limb bud development by identifying the direct transcriptional targets

2021-07-29 | GSE114252 | GEO

Transcriptome of wild type and Shh limb buds at E10.5

Project description:The transcriptome of mouse limb buds of Shh mutant embryos was compared to the transcriptome of limb buds of wild type embryos at embryonic day E10.5

2011-05-01 | E-MEXP-3142 | biostudies-arrayexpress

H3K27ac in WT and Shh-/-, and Shh-/-;Gli3-/- E10.5 limb buds

Project description:H3K27ac in WT and Shh-/-, and Shh-/-;Gli3-/- E10.5 limb buds

| PRJNA552304 | ENA

H3K27ac in WT and Shh-/-, and Shh-/-;Gli3-/- E10.5 limb buds

Project description:Purpose: The response to Hedgehog signaling in the limb is driven by GLI bound enhancers. While most Hh targets in the developing limb bud appear to be regulated by the activity of GLI-repressor, the role of GLI activator in this regulation is unclear. Here we assess the roles of GLI activator and repressor in regulating H3K27ac to activate their enhancers. Methods: ChIP-seq was performed in Embryonic day 10.5 mouse limb buds from WT, Shh-/- and Shh-/-Gli3-/- embryos Results: We found that most GLI binding regions can be activated in the absence of both GLI activator and repressor, while a small subset require GLI activator for activity. These indicate that most GLI enhancers in the limb are regulated by GLI repression.

2020-01-21 | GSE133712 | GEO

SMAD4 Controls Morphogenetic SHH Signaling via Direct Transcriptional Regulation of Cholesterol Biosynthesis in Early Mouse Limb Buds

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-07-29 | GSE114257 | GEO