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Architectural alterations in enhancer repertoires orchestrate senescence-associated secretory phenotype profile [Hi-C]

ABSTRACT: Architectural alterations in enhancer repertoires orchestrate senescence-associated secretory phenotype profile [Hi-C]

PROVIDER: PRJNA481464 | ENA |

REPOSITORIES: ENA

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Architectural alterations in enhancer repertoires orchestrate senescence-associated secretory phenotype profile

Project description:Architectural alterations in enhancer repertoires orchestrate senescence-associated secretory phenotype profile

| PRJNA481463 | ENA

Architectural alterations in enhancer repertoires orchestrate senescence-associated secretory phenotype profile [RNA-seq]

Project description:Architectural alterations in enhancer repertoires orchestrate senescence-associated secretory phenotype profile [RNA-seq]

| PRJNA481465 | ENA

Architectural alterations in enhancer repertoires orchestrate senescence-associated secretory phenotype profile [ChIP-seq]

Project description:Architectural alterations in enhancer repertoires orchestrate senescence-associated secretory phenotype profile [ChIP-seq]

| PRJNA481466 | ENA

Architectural alterations in enhancer repertoires orchestrate senescence-associated secretory phenotype profile [Hi-C]

Project description:The emerging 4D genome project aiming to map the dynamics of genomes in spatial and temporal dimension has put forward to developing the mechanisms of how the nucleus is organized and functions. Therefore, processes like cellular senescence characterized by complex events give rise to understanding the regulation network from 1D genome to dynamically organized 3D structure. Unfortunately, how spatial genome reorganization triggers cellular senescence and how it influences senescence-related downstream transcriptional profile remains unaddressed well. Here, we uncover that re re-orchestration of 3D chromatin architecture has occurred in cellular senescence, accompanied with remodeling of enhancer repertories, which in turn facilicate the recruitment of the chromatin reader C/EBPα to newly activated senescence enhancers (SAEs), leading to the expression of SAEs flanking SASP genes kinetics.

2018-07-18 | GSE117207 | GEO

Architectural alterations in enhancer repertoires orchestrate senescence-associated secretory phenotype profile

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-07-18 | GSE117210 | GEO

Architectural alterations in enhancer repertoires orchestrate senescence-associated secretory phenotype profile [ChIP-seq]

2018-07-18 | GSE117209 | GEO

Architectural alterations in enhancer repertoires orchestrate senescence-associated secretory phenotype profile [RNA-seq]

2018-07-18 | GSE117208 | GEO

Establishment of Enhancer Repertoires that Orchestrate the Myeloid and Lymphoid Cell Fates (ChIP-Seq dataset)

Project description:Recent studies have documented genome-wide binding patterns of transcriptional regulators and their associated epigenetic marks in hematopoietic cell lineages. In order to determine how epigenetic marks are established and maintained during developmental progression, we have generated long-term cultures of hematopoietic progenitors by enforcing the expression of the E-protein antagonist Id2. Hematopoietic progenitors that express Id2 are multipotent and readily differentiate upon withdrawal of Id2 expression into committed B lineage cells, thus indicating a causative role for E2A in promoting the B cell fate. Genome-wide analyses revealed that a substantial fraction of lymphoid and myeloid enhancers are pre-marked by H3K4me1 in multipotent progenitors. However, H3K4me1 levels at a subset of enhancers are elevated during developmental progression, resulting in evolving enhancer repertoires that we propose orchestrate the myeloid and B cell fates.

2011-09-01 | GSE30858 | GEO

Establishment of Enhancer Repertoires that Orchestrate the Myeloid and Lymphoid Cell Fates (gene expression dataset 2)

2011-09-01 | GSE30856 | GEO

Establishment of Enhancer Repertoires that Orchestrate the Myeloid and Lymphoid Cell Fates (gene expression dataset 1)

2011-09-01 | GSE30855 | GEO