Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Childhood Cerebellar Tumors Mirror Conserved Fetal Transcriptional Programs

ABSTRACT: Childhood Cerebellar Tumors Mirror Conserved Fetal Transcriptional Programs

PROVIDER: PRJNA484319 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7641091.fastq.gz	Fastqsanger.gz
	SRR7641092.fastq.gz	Fastqsanger.gz
	SRR7641093.fastq.gz	Fastqsanger.gz
	SRR7641094.fastq.gz	Fastqsanger.gz
	SRR7641095.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 9

Similar Datasets

Childhood Cerebellar Tumors Mirror Conserved Fetal Transcriptional Programs

Project description:The study of the origin and development of cerebellar tumours has been hampered by the complexity and heterogeneity of cerebellar cells that change over the course of development. We used single-cell transcriptomics to study >60,000 cells from the developing murine cerebellum, and show that different molecular subgroups of childhood cerebellar tumours mirror the transcription of cells from distinct, temporally restricted cerebellar lineages. Sonic Hedgehog medulloblastoma transcriptionally mirrors the granule cell hierarchy as expected, whereas Grp3-MB resemble Nestin+ve stem cells, Group 4 medulloblastomas resemble unipolar brush cells, and PFA/PFB ependymoma and cerebellar pilocytic astrocytoma resemble the pre-natal gliogenic progenitor cells. Furthermore, single-cell transcriptomics of human childhood cerebellar tumours demonstrates that many bulk tumours contain a mixed population of cells with divergent differentiation. Our data highlight cerebellar tumours as a disorder of early brain development, and provide a proximate explanation for the peak incidence of cerebellar tumours in early childhood.

2019-05-01 | GSE118068 | GEO

Childhood cerebellar tumors mirror conserved fetal transcriptional programs

Project description:We used single-cell transcriptomics to study >60,000 cells from the developing murine cerebellum, and show that different molecular subgroups of childhood cerebellar tumors mirror the transcription of cells from distinct, temporally restricted cerebellar lineages.

| EGAS00001003170 | EGA

Childhood cerebellar tumours mirror conserved fetal transcriptional programs.

Project description:Study of the origin and development of cerebellar tumours has been hampered by the complexity and heterogeneity of cerebellar cells that change over the course of development. Here we use single-cell transcriptomics to study more than 60,000 cells from the developing mouse cerebellum and show that different molecular subgroups of childhood cerebellar tumours mirror the transcription of cells from distinct, temporally restricted cerebellar lineages. The Sonic Hedgehog medulloblastoma subgroup transcriptionally mirrors the granule cell hierarchy as expected, while group 3 medulloblastoma resembles Nestin+ stem cells, group 4 medulloblastoma resembles unipolar brush cells, and PFA/PFB ependymoma and cerebellar pilocytic astrocytoma resemble the prenatal gliogenic progenitor cells. Furthermore, single-cell transcriptomics of human childhood cerebellar tumours demonstrates that many bulk tumours contain a mixed population of cells with divergent differentiation. Our data highlight cerebellar tumours as a disorder of early brain development and provide a proximate explanation for the peak incidence of cerebellar tumours in early childhood.

| S-EPMC6675628 | biostudies-literature

MAGIC_RNA-Seq_MBs_bulkRNAseq_A_ids - samples

Project description:Childhood cerebellar tumours mirror conserved fetal transcriptional programs

| EGAD00001004435 | EGA

Metabolome analysis in the diagnosis of childhood cerebellar ataxia

Project description:Metabolome studies to aid in the diagnosis and molecular elucidation of a child presenting chronic progressive cerebellar ataxia and an undiagnosed condition.

2020-10-20 | ST001518 | MetabolomicsWorkbench

Developmental programs in childhood neuroblastoma [scRNA-seq SK-N-AS]

Project description:Developmental programs in childhood neuroblastoma [scRNA-seq SK-N-AS]

| PRJNA686095 | ENA

32ec0dbb-03e4-429e-b406-c610c3ca60f9 - samples

| EGAD00001004318 | EGA

Epigenetic control of region specific transcriptional programs in mouse cerebellar and cortical astrocytes

Project description:Epigenetic control of region-specific transcriptional programs in mouse cerebellar and cortical astrocytes

| PRJEB31136 | ENA

Cyprinus carpio 'Songpu mirror carp'

Project description:Cyprinus carpio 'Songpu mirror carp' Genome sequencing

| PRJNA202478 | ENA