Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Establishment and disease modeling of non-small cell lung cancer organoids

ABSTRACT: Establishment and disease modeling of non-small cell lung cancer organoids

PROVIDER: PRJNA487654 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Establishment and disease modeling of non-small cell lung cancer organoids

Project description:Purpose: The goal of this study is to establish and molecularly characterize non-small cell lung cancer (NSCLC) organoids. Generation of NSCLC organoids would provide additional preclinical models for drug screening and biomarker discovery. Methods: Patient lung tumors and previously established patient-derived xenografts (PDX) were processed to generate organoids. Total RNA was extracted and subjected to RNA-seq to examine the gene expression similarity between patient/PDX/organoid of the same model using t-SNE clustering. Results: Through RNA-sequencing, we generated TPM values of patient, PDX and organoid samples of 5 models. t-SNE analysis showed that the patient/PDX/organoid of the same models clustered together. The lung adenocarcinoma samples formed a separate cluster from the squamous cell carcinoma samples based on gene expression. Conclusions: Our study introduces the establishment of NSCLC organoids and demonstrates the gene expession similarity of the organoid model to its corresponding PDX and patient sample.

2019-11-26 | GSE119004 | GEO

Modeling PD in midbrain-like organoids

Project description:Modeling PD in midbrain-like organoids

| PRJNA525884 | ENA

Modeling Genetic Epileptic Encephalopathies using Brain Organoids

Project description:We generated cerebral organoids from genetically engineered human embryonic stem cells (hESCs), modeling the devastating WOREE syndrome (DEE28), as a prototype for genetic epileptic encephalopathies (EEs). Transcriptome analysis of mutated organoids compared to the WT revealed molecular changes related to both early infantile EEs and specifically to WOREE syndrome.

2021-07-01 | GSE156243 | GEO

Establishment and characterization of prostate cancer organoids

Project description:Establishment and characterization of prostate cancer organoids

| PRJNA454345 | ENA

Establishment and characterization of prostate cancer organoids

Project description:Establishment and characterization of prostate cancer organoids

| PRJNA453902 | ENA

Establishment and characterization of prostate cancer organoids

Project description:Establishment and characterization of prostate cancer organoids

| PRJNA454346 | ENA

Modeling Genetic Epileptic Encephalopathies using Brain Organoids

Project description:Modeling Genetic Epileptic Encephalopathies using Brain Organoids

| PRJNA657175 | ENA

Establishment of intestinal organoid cultures modeling injuryassociated epithelial regeneration

Project description:Establishment of intestinal organoid cultures modeling injuryassociated epithelial regeneration

| PRJNA693445 | ENA

Establishment and characterization of prostate cancer organoids [array]

Project description:Establishment and characterization of prostate cancer organoids [array]

| PRJNA453752 | ENA

Modeling oxidative injury response in human kidney organoids

Project description:Modeling oxidative injury response in human kidney organoids

| PRJNA755987 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data