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Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [origins]

ABSTRACT: Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [origins]

PROVIDER: PRJNA487777 | ENA |

REPOSITORIES: ENA

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Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors

Project description:Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors

| PRJNA487779 | ENA

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [development]

Project description:Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [development]

| PRJNA487781 | ENA

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [origins]

Project description:Purpose: The purpose is to systemically identify RNA expression between skin mast cells with distinct origins. Methods: We profiled RNA-seq in skin mast cells with distinct origins. Results: Early, late EMP and fetal HSC-derived skin mast cells display distinct transcriptome profiles.

2018-10-05 | GSE119016 | GEO

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [development]

Project description:Purpose: The purpose is to systemically identify RNA expression changes along mast cell development during embryogenesis. Methods: We profiled RNA-seq in early EMPs and their progeny. Results: Fetal MCPs acquire the mast cell-specific gene signature from E11.5 and complete their maturation in peripheral tissues.

2018-10-15 | GSE119017 | GEO

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-10-09 | GSE119018 | GEO

Human connective tissue mast cell proteome

Project description:Mast cells are hematopoietic cells that reside preferentially in tissues exposed to internal and external environments. Mast cells sense immunological, inflammatory and environmental stimuli, and can be activated to release granules and generate inflammatory mediators. Mast cell-derived products confer protection against snake venoms and some parasite infections. Aberrant activation of mast cells is a major contributor to human pathology, including allergy, asthma and adverse drug reactions. Their strict tissue location has largely impeded the isolation of large numbers of primary mast cell for further analysis. To better understand the biology of mast cells, we analyzed the proteome of primary human and mouse mast cells by quantitative mass spectrometry. We identified a mast cell-specific protein signature that was conserved from mouse to man. Compared to a comprehensive set of other immune cell lineages, proteome analysis identified a unique and distant mast cell cluster. The mast cell signature included proteins governing granule biosynthesis and secretion, as well as proteoglycan- and neurotransmitter metabolism. Proteome conservation across species suggests evolutionary maintenance of mast cell functions.

2020-02-12 | PXD014978 | Pride

Mouse connective tissue mast cell proteome

2020-02-12 | PXD015040 | Pride

Expression data from mouse mast cell progenitors, mature mast cells and innate lymphoid cells of type 2

Project description:Mast cells originate from the bone marrow and develop into c-kit+ FcεRI+ cells. As both mast cell progenitors and mature mast cells express these cell surface markers, ways validated to distinguish between the two maturation forms with flow cytometry have been lacking. We identified and sorted two distinct populations of mast cells from mouse peritoneum. Gene expression microarray analyses were used to confirm the maturation statuses of the mast cell populations.

2015-03-07 | GSE63507 | GEO

Single-cell transcriptional profiling of late mast cell differentiation in mouse

Project description:Single-cell RNA sequencing of Lin- c-Kit+ FcεRI+ cells from mouse peritoneum captured the late mast cell differentiation

2020-10-20 | GSE128003 | GEO

Bach Factors Operate Erythro-Myeloid Differentiation by Responding to Infection

Project description:Hematopoietic cell differentiation should be tightly regulated in accordance with environmental changes to keep homeostasis. Infection is one of the conditions that induce myelopoiesis to exclude pathogens and repress erythropoiesis, which might be beneficial for the restriction of nutritional iron for pathogens. While several transcription factors (TFs), including C/EBP family and Gata1, play central roles in erythro-myeloid differentiation, the precise mechanism which controls the differentiation for the adaptation to infection remains obscure. In this study, it was revealed that Bach factors induce erythropoiesis and repress myelopoiesis in the erythro-myeloid bifurcation step, and their expressions per se were suppressed by infectious stimuli. Hence, they work as balancers of the erythro-myeloid differentiation between steady state and infectious state. These findings give us new insight into the machinery which regulates the fate of hematopoietic cells by responding to surrounding environments.

2018-09-26 | GSE86253 | GEO

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