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Effect of metformin on 24 hour culture of SLE CD4 T cells and Healthy Control CD4 T cells

ABSTRACT: Effect of metformin on 24 hour culture of SLE CD4 T cells and Healthy Control CD4 T cells

PROVIDER: PRJNA489267 | ENA |

REPOSITORIES: ENA

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Effect of metformin on 24 hour culture of SLE CD4 T cells and Healthy Control CD4 T cells

Project description:Effect of metformin on 24 hour culture of SLE CD4 T cells and Healthy Control CD4 T cells

| PRJNA489267 | ENA

Effect of metformin on 24 hour culture of SLE CD4 T cells and Healthy Control CD4 T cells

Project description:Investigate the effect of 1.0 mM Metformin on CD4 T cells from Systemic Lupus Patients and compare to Healthy Control CD4 T cells

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SLE and atherosclerosis CD4+ T-cell RNAsequencing

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2024-10-10 | E-MTAB-13443 | biostudies-arrayexpress

Investigation of gene expression profiles in CD4+ T cells from SLE patients and normal controls

Project description:To investigate the lncRNAs expression profiling in CD4+ T cells of systemic lupus erythematosus (SLE) patients, we have employed “Agilent Human lncRNA 4*180K microarray” as a discovery platform to identify lncRNAs and mRNAs expression signatures in CD4+ T cells between SLE patients and normal controls. CD4+ T cells were isolated from peripheral blood mononuclear cells (PBMCs) of peripheral blood in SLE patients and normal controls, respectively.

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Project description:Purpose: To investigate the effects of metabolic inhibitors metformin and 2-deoxyglucose on the global transcriptome of primary human CD4+ T cells. Methods: mRNA profiles of primary human CD4+ T cells were generated by RNA-Seq for 3 donors in triplicate using Illumina TruSeq library prep. Data was processed using Elucidata's workflow as described below. Results: Our study presents the first transcriptomic analysis of how metformin + 2-deoxyglucose combination treatment affects activation-induced remodeling of metabolic gene expression in primary human CD4+ T cells.

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Smart RNA sequencing Facilitates Quantitative Analysis of dermal CD4+ Trm cells between SLE and NC.

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RNA-Sequencing of CD4, CD8 and CD19 splenocytes from mouse models of SLE

Project description:Systemic Lupus Erythematosus (SLE) is an autoimmune disease that affects 20-150 out of 100,000 people globally. Reactive oxygen species (ROS) generation from mitochondrial dysfunction contributes to risk for SLE and autoimmune states and are potential targets for the treatment of autoimmunity. HRES-1/Rab4 (Rab4A) is a GTPase linked to mitochondrial oxidative stress and activation of the mechanistic target of rapamycin (mTOR), and has been linked to SLE pathogenesis. Here, RNA-sequencing (RNA-seq) was used to examine the expression of different classes of splenocytes (CD4+, CD8+, CD19+) from the lupus-prone SLE1.2.3. triple-congenic (B6.TC) mouse, as well as Rab4AQ72L mutant mice (which exhibits constitutive overexpression of Rab4a), and mice with CD4 T cell-specific deletion of Rab4A (KO).

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A novel CD4 T cell population expanded in SLE blood provides B cell help through IL10 and succinate [ATAC-seq]

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Project description:We screened SLE monocytes from 19 SLE patients and selected 4 that induced CD4+ T cell proliferation in vitro and 4 that did not. CFSE labeled CD4-T cells (105) were incubated with SLE monocytes (2 x 104). Cells were harvested at 6 hours for RNA extraction. We screened SLE monocytes from 19 SLE patients and selected 4 that induced CD4+ T cell proliferation in vitro and 4 that did not. CFSE labeled CD4-T cells (105) were incubated with SLE monocytes (2 x 104). Cells were harvested at 6 hours for RNA extraction.

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