Kolotl magnus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA491525 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Desulfonatronovibrio magnus overview
| PRJNA286017 | ENA
Project description:Hesperophylax magnus HiFi Genome sequencing and assembly
| PRJNA846308 | ENA
Project description:Desulfonatronovibrio magnus strain:AHT22 Genome sequencing and assembly
| PRJNA262433 | ENA
Project description:Agrypnia vestita and Hesperophylax magnus Genome sequencing and assembly
| PRJNA668166 | ENA
Project description:The spinal cord after injury shows altered transcription in numerous genes. We tested in a pilot study whether the nucleus raphé magnus, a descending serotonergic brainstem region whose stimulation improves recovery after incomplete spinal cord injury, can influence these transcriptional changes. Rats received 2 hours of low-frequency electrical stimulation in the raphé magnus three days after an impact contusion at segment T8. Comparison groups lacked injuries or activated stimulators or both. Immediately following stimulation, spinal cords were extracted, their RNA transcriptome sequenced, and differential gene expression quantified. Confirming many previous studies, injury primarily increased inflammatory and immune transcripts and decreased those related to lipid and cholesterol synthesis and neuronal signaling. Stimulation plus injury, contrasted with injury alone, caused significant changes in 43 transcripts (39 increases, 4 decreases), all protein-coding. Injury itself decreased only four of these 43 transcripts, all reversed by stimulation, and increased none of them. The non-specific 5-HT7 receptor antagonist pimozide reversed 25 of the 43 changes. Stimulation in intact rats principally caused decreases in transcripts related to oxidative phosphorylation, none of which were altered by stimulation in injury. Gene ontology (biological process) annotations comparing stimulation with either no stimulation or pimozide treatment in injured rats highlighted defense responses to lipopolysaccharides and microorganisms, and also erythrocyte development and oxygen transport (possibly yielding cellular oxidant detoxification). Connectivity maps of human orthologous genes generated in the CLUE database of perturbagen-response transcriptional signatures showed that drug classes whose effects in injured rats most closely resembled stimulation without pimozide include peroxisome proliferator-activated receptor agonists and angiotensin receptor blockers, which are reportedly beneficial in spinal cord injury. Thus, the initial transcriptional response of injured spinal cord to raphé magnus stimulation is upregulation of genes that in various ways are mostly protective, some probably located in recently arrived myeloid cells.
2019-11-03 | GSE133093 | GEO
Project description:Interest in platinum-chain complexes arose from their unusual oxidation states and physical properties. Despite their compositional diversity, isolation of crystalline chains has remained challenging. Here we report a simple crystallization technique that yields a series of dimer-based 1D platinum chains. The colour of the Pt(2+) compounds can be switched between yellow, orange and blue. Spontaneous oxidation in air is used to form black Pt(2.33+) needles. The loss of one electron per double salt results in a metallic state, as supported by quantum chemical calculations, and displays conductivity of 11?S?cm(-1) at room temperature. This behaviour may open up a new avenue for controllable platinum chemistry.
| S-EPMC4915127 | biostudies-literature
Project description:Bacteriophage Magnus infects Klebsiella pneumoniae, a Gram-negative pathogen whose multidrug-resistant strains are a public health issue. Here, we describe the annotation of the 157,741-bp Magnus genome and its similarity to other myophages.
| S-EPMC6763660 | biostudies-literature
Project description:Hip adduction is accomplished through coordinated effort of the adductor magnus, brevis, and longus and the obturator externus and pectineus muscles. Each of these muscles may be injured at its proximal or distal insertion or in its midsubstance. The incidence of injuries to the adductor complex is difficult to determine in sport because of players' underreporting and playing through minor strains. The most commonly injured adductor muscle is the adductor longus muscle. The injury most frequently occurs at the proximal or distal musculotendinous junction, but several case reports of origin and insertional ruptures of the adductor longus exist in the literature. Successful outcomes have been obtained with both operative and nonoperative approaches in these cases. Reports of isolated proximal avulsion of the adductor magnus are less common. This article describes our surgical technique for management of a rare acute proximal adductor magnus avulsion.
| S-EPMC6408720 | biostudies-literature
Project description:We investigate the role of resident memory T cells in protective immunity in HIV infection Funding sources: Michael R. Betts: NIH/NIAID R01 AI076066 and R01 AI118694 Marcus Buggert: Swedish Research Council (Dnr 537-2014-6829), Karolinska Institutet, Magnus Bergvall and Lars Hiertas Stiftelse
2019-02-15 | GSE110684 | GEO
Project description:Interventions: A group:Before using cetuximab;B group:After progression of disease:no
Primary outcome(s): KRAS gene sequence;NRAS gene sequence;BRAF gene sequence;PIK3CA gene sequence;EGFR gene sequence;EGFR gene copy numbers;EGFR expression;Her2 expression;c-Met expression;PTEN expression
Study Design: historical control
| 2671639 | ecrin-mdr-crc