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RNA-Seq of human induced pluripotent stem cell-derived cardiomyocytes from a cardiomyopathy patient and familial control

ABSTRACT: RNA-Seq of human induced pluripotent stem cell-derived cardiomyocytes from a cardiomyopathy patient and familial control

PROVIDER: PRJNA497794 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8083720.fastq.gz	Fastqsanger.gz
	SRR8083721.fastq.gz	Fastqsanger.gz
	SRR8083722.fastq.gz	Fastqsanger.gz
	SRR8083723.fastq.gz	Fastqsanger.gz
	SRR8083718.fastq.gz	Fastqsanger.gz

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RNA-Seq of human induced pluripotent stem cell-derived cardiomyocytes from a cardiomyopathy patient and familial control

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Project description:Different single mutations on the same sarcomeric gene often cause distinct cardiomyopathy phenotypes as dilated (DCM) or hypertrophic cardiomyopathy (HCM). The key factors involved in this disease divergence is unknown and could be key for disease intervention.We generated isogenic familial DCM and HCM disease-specific human embryonic stem cells (hESCs) carrying the cTnT-DK210 and -DE160 mutation, respectively. Whole transcriptomic RNA-sequencing was used to identify the key gene involved in the earliest disease divergence of cTnT-DK210 caused DCM and cTnT-DE160 caused HCM. Results provide insight into the new molecular mechanisms underlying familial dilated cardiomyopathy.

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