Project description:This model, iPau21, updates and extends the genome-scale metabolic model of the harmful pathogen Pseudomonas aeruginosa UCBPP-PA14, initially published by Bartell et al. (2017). This new model incorporates new information and extensive annotation additions based on manual literature curation. The model was validated using MEMOTE to demonstrate its ability to grow on known carbon sources for this organism, gene essentiality, and additional capabilities. The model was contextualized with transcriptomic data that demonstrate its growth capabilities and differential utilization of fumarate metabolism while also revealing an increased utilization of propionate metabolism upon MUC5B exposure.
