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Investigate the affect of CASZ1b on chromatin accessibility in SMS-CTR cells

ABSTRACT: Investigate the affect of CASZ1b on chromatin accessibility in SMS-CTR cells

PROVIDER: PRJNA521144 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8539501_1.fastq.gz	Fastqsanger.gz
	SRR8539501_2.fastq.gz	Fastqsanger.gz
	SRR8539502_1.fastq.gz	Fastqsanger.gz
	SRR8539502_2.fastq.gz	Fastqsanger.gz

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Investigate the affect of CASZ1b on chromatin accessibility in SMS-CTR cells

Project description:In SMS-CTR cells, the overexpression of CASZ1b in SMS-CTR cells led to a modification of regional chromation accessibility.

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RNA-sequencing analysis to investigate genes regulated by CASZ1 in SMS-CTR cells

Project description:In this study we identified genes regulated by CASZ1b in SMS-CTR cells

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Genome-wide mapping of CASZ1b binding sites and investigate its effect on chromatin status in SMS-CTR cells [CTRtetCASZ1b]

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Genome-wide mapping of CASZ1 binding sites in differentiated SMS-CTR cells [Trametinib]

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RNA-sequencing analysis to investigate genes regulated by CASZ1 in SMS-CTR cells

Project description:RNA-sequencing analysis to investigate genes regulated by CASZ1 in SMS-CTR cells

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Genome-wide mapping of CASZ1b binding sites and investigate its effect on chromatin status in SMS-CTR cells [CTRtetCASZ1b]

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Chromatin states and transcription factor binding in SIX1 deficient Rhabdomyosarcoma cells

Project description:Genetic and shRNA-mediated inhibition of SIX1 expression in RMS cells induces myogenic differentiation and impedes RMS tumor growth. To elucidate the mechanism by which SIX1 loss activates a differentiation program, we performed SIX1, MYOD1, and H3K27ac ChIPseq in two SIX1 knockdown SMS-CTR cell lines and one control SMS-CTR cell line to profile changes in transcriptional activity and myogenic transcription factor binding in fusion-negative Rhabdomyosarcoma.

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