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To investigate whether recover DNMT3A expression permitted adult beta cell of βRapKO establishing proper transcriptome

ABSTRACT: To investigate whether recover DNMT3A expression permitted adult beta cell of βRapKO establishing proper transcriptome

PROVIDER: PRJNA541937 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR9030020_1.fastq.gz	Fastqsanger.gz
	SRR9030020_2.fastq.gz	Fastqsanger.gz
	SRR9030021_1.fastq.gz	Fastqsanger.gz
	SRR9030021_2.fastq.gz	Fastqsanger.gz
	SRR9030022_1.fastq.gz	Fastqsanger.gz

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To investigate whether recover DNMT3A expression permitted adult beta cell of βRapKO establishing proper transcriptome

Project description:Murine islets were isolated from 8-week-old WT and βRapKO mice and initially recovered in 1640 RPMI supplemented with 10% serum, 11.1mM glucose overnight. Then islets were transfected with Lenti-GFP or Lenti-Dnmt3a for 24 hours, following cultured in 1640 RPMI medium for 48 hours.Islets were harvested and stored in -80°C for preparation for RNA sequencing.

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