Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA sequencing analysis of wildtye and Acc2 iKO mice heart in chow and HFD

ABSTRACT: RNA sequencing analysis of wildtye and Acc2 iKO mice heart in chow and HFD

PROVIDER: PRJNA542673 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9049550_1.fastq.gz	Fastqsanger.gz
	SRR9049550_2.fastq.gz	Fastqsanger.gz
	SRR9049560_1.fastq.gz	Fastqsanger.gz
	SRR9049560_2.fastq.gz	Fastqsanger.gz
	SRR9049551_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 40

Similar Datasets

RNA sequencing analysis of wildtye and Acc2 iKO mice heart in chow and HFD

Project description:Here, we show that short term HFD feeding did not change the cardiac function in normal (Con) and increased FAO mice (ACC2 iKO). RNA sequencing analysis show that ACC2 can have small but significant genetic perturbations impact on the global transcriptome under chow and HFD condition. Most of fatty acid degradation and PPAR signaling pathway related gene transcription levels were decreased by knocking out ACC2. Intriguingly, cardiac transcriptome analysis of several lipotoxicity mouse models showed an opposite regulation direction of PPAR signaling pathway and fatty acid degradation genes. Finally, fatty acid degradation gene transcription was found back to normal in iKO-HFD mouse hearts compared to Con-chow mice hearts. These results suggest that fatty acid availability may play an important role in PPAR signaling regulation regardless the fatty acid oxidation rate, at least in mice heart.

2020-03-31 | GSE131122 | GEO

Proteomics of liver from mice fed high fat diet (HFD) or regular chow diet

Project description:Proteomics of liver tissue from mice fed a high fat diet (HFD) or regular chow diet. Data accompany our paper entitled “Dynamic Regulation of N6,2′-O-dimethyladenosine (m6Am) in Obesity” scheduled for publication in Nature Communications, 2021

2021-10-27 | PXD029280 | Pride

RNA Sequencing Analysis of liver from Normal Chow, HFD Control and SZ-A-treated HFD mice

Project description:Ramulus Mori (Sangzhi) alkaloids (SZ-A) alleviates nonalcoholic fatty liver disease in mice. This study compares transcriptome profiling (RNA-seq) in the liver of normal chow, high-fat diet (HFD) control and SZ-A-treated HFD mice to verify the regulatory mechanisms of SZ-A. These results demonstrated that SZ-A regulates lipid metabolism and metabolic stress-induced inflammation and fibrosis.

2022-03-23 | GSE199105 | GEO

Gene expression in chow or HFD-fed OGG1-/- livers

Project description:Gene expression in livers of male wild-type (WT) and OGG1-deficient (Ogg1-/-) mice fed either a chow diet or a high-fat diet (HFD) were examined. Mice were fed the diet for 10 weeks prior to tissue collection and were 22 weeks of age at the time of tissue collection. 24 Total samples were analyzed. We generated the following pairwise comparisons using GeneSifter: WT Chow vs Ogg1-/- Chow; WT HFD vs. Ogg1-/- HFD using t-test followed by Benjamini and Hochberg correction. An adjusted p-value less than 0.05 was considered to be statistically significant.

2012-12-16 | E-GEOD-35497 | biostudies-arrayexpress

RNA Sequencing Analysis of the epididymal adipose tissue from Normal Chow, HFD Control and SZ-A-treated HFD mice

Project description:Ramulus Mori (Sangzhi) alkaloids (SZ-A) improves lipid metabolism and adipose tissue inflammation in HFD-induced obese mice.This study compares transcriptome profiling (RNA-seq) in the epididymal adipose tissue of normal chow, high-fat diet (HFD) control and SZ-A-treated HFD mice to verify the regulatory mechanisms of SZ-A. These results demonstrated that SZ-A regulates lipid metabolism and inflammation.

2022-11-20 | GSE214618 | GEO

Genome-wide expression profile of livers from mice fed HFD,SO-HFD or Viv chow [RNAseq]

Project description:Purpose: Aim of the study is to identify changes in hepatic gene expression induced by either a 40kcal% coconut oil rich high fat diet (HFD), a 40kcal% soybean oil plus coconut oil high fat diet (SO-HFD) or a low fat vivarium chow diet (Viv). Methods: Livers from mice that had been fed one of the above mentioned diets for 35 weeks, were used to make cDNA libraries that were then sent for deep sequencing, using the Illumina TruSeq RNA. Result: Many genes involved in metabolism, lipid binding, transport and storage and many Cyp genes are dysregulated in the two high fat diets as compared to Viv HFDs in SO-HFD mice. Comparing the two HFDs shows more metabolism and disease related genes dysregulated in SO-HFD vs HFD. Conclusion: A diet high in soybean oil may be more detrimental to metabolic health than a diet high in saturated fats. cDNA isolated from livers from mice fed HFD, SO-HFD or Viv for 35 weeks, were 50bp pair-ended sequenced in triplicate using Illumina TruSeq RNA Sample Prep v2 Kit.

2015-08-28 | E-GEOD-68360 | biostudies-arrayexpress

RNA Sequencing Analysis of liver from Normal Chow, HFD Control and SZ-A-treated HFD mice

Project description:RNA Sequencing Analysis of liver from Normal Chow, HFD Control and SZ-A-treated HFD mice

| PRJNA818356 | ENA

Genome-wide expression profile of livers from mice fed HFD,SO-HFD or Viv chow [RNAseq]

2015-08-28 | GSE68360 | GEO

Gene expression in chow or HFD-fed OGG1-/- livers

2012-12-16 | GSE35497 | GEO

Hypothalamic astrocytes TRAP-seq in ORX/HFD mice

Project description:3' mRNA-sequencing of the immunoprecipitated and supernatant fractions after Translating Ribosome Affinity Purification (TRAP) targeted to hypothalamic astrocytes RNA (from Aldh1l1eGFP-L10a mice) for 3 experimental conditions: chow diet; high-fat diet; high-fat diet + orchiectomy (Sham-chow n=7, Sham-HFD n=6, ORX-HFD n=7)

2023-04-03 | GSE214683 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data