Project description:detoxin S1 source strain Streptomyces sp. S-325 (JOIW01) raw UHPLC-MS data and representative MS2 detoxins N1, N2, N3 source strain Streptomyces spectabilis NRRL 2792 raw UHPLC-MS data and representative MS2 detoxins N2, N3 source strain Streptomyces sp. NRRL B-1347 (JOJM01) raw UHPLC-MS data detoxins P1, P2, P3 source strain Amycolatopsis jujuensis NRRL B-24427 raw UHPLC-MS data and representative MS2

2019-04-01 | MSV000083648 | MassIVE

Streptomyces spectabilis strain:CECT 3146 | isolate:CECT 3146

Project description:Streptomyces spectabilis CECT 3146 genome sequencing

| PRJNA546741 | ENA

Ribosome pausing at the AT-rich codons regulates the protein expression of secondary metabolite gene clusters in the Streptomyces tsukubaensis NRRL 18488

Project description:Streptomyces tsukubaensis NRRL 18488 is the preferred strain for the production of immunosuppressant agent tacrolimus (FK506). To take full advantage of its genetic potential, systematic understanding of secondary metabolism and related regulatory mechanisms is highly demanded. Here, to this end, we complete its 7.9 Mbp linear genome sequence followed by integrating with multi-omics measurements. With accurate reannotation of FK506 gene cluster, total 2,389 transcription start sites were determined by using primary transcriptome analysis. Integrated analysis of transcriptome and translatome data revealed that secondary metabolic gene clusters, especially FK506 cluster, undergo translational control with decrease in translational efficiency according to the growth. Furthermore, we demonstrated that SD motif has little correlation with ribosome pausing but AT-rich codons delay the translational elongation. Strong ribosome pausing was observed in the rare TTA codon in FK506 cluster. This comprehensive genome-scale analysis provides insight to the translational regulation of secondary metabolism in S. tsukubaensis.

2019-10-16 | GSE97637 | GEO

Radiomyces spectabilis strain:RSA627

Project description:Radiomyces spectabilis NRRL 2753 Transcriptome

| PRJNA403074 | ENA

Radiomyces spectabilis strain:RSA627

Project description:Radiomyces spectabilis NRRL 2753 Transcriptome

| PRJNA403317 | ENA

Dipodomys spectabilis isolate:Male_0828

Project description:Dipodomys spectabilis isolate:Male_0828 Genome sequencing and assembly

| PRJNA730493 | ENA

Expression analysis of Candida tenuis NRRL Y-1498 grown in glucose or xylose

Project description:Investigation of whole genome gene expression level changes in Candida tenuis NRRL Y-1498 grown aerobically in xylose, compared to the same strain grown aerobically in glucose.

2011-10-20 | GSE24856 | GEO

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