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Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells [ChIP-seq]

ABSTRACT: Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells [ChIP-seq]

PROVIDER: PRJNA548750 | ENA |

REPOSITORIES: ENA

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Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells

Project description:Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells

| PRJNA548746 | ENA

Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells [RNA-seq]

Project description:We collected significant amount of phenotypic and mechanistic data from a ATF4 knockout mouse model and demonstrated that HSC defects with an aging-like phenotype (expanded pool of phenotypical HSCs, decreased number of functional HSCs, impaired repopulating and self-renewal capacities of HSCs and myeloid bias) occurred in the ATF4 KO mice, suggesting that not only ATF4 indeed represents a pivotal factor for adult HSC function but also we had successfully constructed an ideal and attractive model to study aging and aging-related disease.

2021-12-29 | GSE132682 | GEO

Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells [RNA-seq]

Project description:Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells [RNA-seq]

| PRJNA548749 | ENA

Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells [ChIP-seq]

Project description:Human acute myeloid leukemia (AML) KG1a cells or mouse BM cells (mouse bone morrow cells were employed for each ChIP assay. The ChIP procedure was performed according to a previously described protocol (Lee et al., 2006; Ying et al., 2017), using anti-ATF4 antibody (Abcam)

2021-12-29 | GSE132681 | GEO

Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells.

Project description:[Figure: see text].

| S-EPMC8694622 | biostudies-literature

Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-12-29 | GSE132683 | GEO

ATF4 regulates MYB to increase g-globin in response to loss of β-globin [ChIP-seq]

Project description:Boontanrart et al model the cellular stress that occurs upon reduction in β-globin in human erythroid cells. Decrease in β-globin attenuates the eIF2aP-ATF4 pathway and results in upregulating fetal -globin. Down-regulation of ATF4 leads to decreased levels of the -globin repressor MYB through direct binding at the HBS1L-MYB intergenic region.

2020-07-26 | GSE153767 | GEO

ATF4 regulates MYB to increase g-globin in response to loss of β-globin [RNA-seq]

Project description:Boontanrart et al model the cellular stress that occurs upon reduction in β-globin in human erythroid cells. Decrease in β-globin attenuates the eIF2aP-ATF4 pathway and results in upregulating fetal g-globin. Down-regulation of ATF4 leads to decreased levels of the g-globin repressor MYB through direct binding at the HBS1L-MYB intergenic region.

2020-07-26 | GSE153764 | GEO

Nucleosome loss leads to global transcriptional upregulation and genomic instability during yeast replicative aging

Project description:All eukaryotic cells divide a finite number of times, termed replicative aging, but the reason for this is not clear. Consistent with the decreased total histone protein levels in aged Saccharomyces cerevisiae, which is a cause of aging (1), we find that nucleosome occupancy decreases 50% across the whole genome during replicative aging by spike-in controlled MNase sequencing. Nucleosomes become fuzzier or move to sequences predicted to better accommodate histone octamers. All yeast genes are induced during aging. Genes that are repressed in young cells are most induced, accompanied by nucleosome loss from their promoters that have unique chromatin organization. Contrary to the loss of mitochondrial function during aging, mitochondrial DNA content increases and unprecedented levels of large-scale chromosomal alterations and increased retrotransposition are observed. Mnase-Seq experiments were carried out for young yeast, old yeast, and old yeast with histone over expression, 3 replicates were done for each category. RNA-Seq were carried out for the same categories of yeast cells but with 2 replicates for each. Genome-Seq were done for the young and old yeast with 2 replicates for each.

2014-02-26 | E-GEOD-47023 | biostudies-arrayexpress

RNA-seq of muscles from young and aged ATF4 mKO mice and littermate controls

Project description:To investigate the roles of ATF4 in skeletal muscle aging we generated muscle-specific ATF4 knockout (ATF4 mKO) mice. We then performed gene expression profiling analysis using data obtained from RNA-seq of tibialis anterior muscles at 6-months and 22-months of age.

2023-05-02 | GSE212675 | GEO

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