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Chromatin-associated RNAchIP and transcriptome analyses of the relationship between HP1g/CBX3 and RNA [RNA-seq]

ABSTRACT: Chromatin-associated RNAchIP and transcriptome analyses of the relationship between HP1g/CBX3 and RNA [RNA-seq]

PROVIDER: PRJNA550673 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9600570_1.fastq.gz	Fastqsanger.gz
	SRR9600570_2.fastq.gz	Fastqsanger.gz
	SRR9600561_1.fastq.gz	Fastqsanger.gz
	SRR9600561_2.fastq.gz	Fastqsanger.gz
	SRR9600571_1.fastq.gz	Fastqsanger.gz

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Chromatin-associated RNAchIP and transcriptome analyses of the relationship between HP1g/CBX3 and RNA [RNA-seq]

Project description:RNA-seq and RNAchIP-seq experiments were performed on MEF-derived cell lines knock-out for the expression of HP1g/CBX3 (R cell line) or recomplemented for the expression of HP1g (HPg cell line). Cells were tested under normal growth or conditions of stress (p samples) by treatment with the phorbol ester PMA. Each experiment was performed in biological triplicates.

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Chromatin-associated RNAchIP and transcriptome analyses of the relationship between HP1g/CBX3 and RNA

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Chromatin-associated RNAchIP and transcriptome analyses of the relationship between HP1g/CBX3 and RNA [RIP-seq]

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Genome-wide mapping of Cbx3/HP1g deposition in wild-type CD8+ effector T cells

Project description:We report the application of Illumina Hi-Seq sequencing technology for high-throughput profiling of Cbx3/HP1g deposition in mammalian CD8+ effector T cells. By obtaining over four billion bases of sequence from chromatin immunoprecipitated DNA, genome-wide chromatin-state maps of mouse wt CD8+ effector T cells were generated. We find that Cbx3/HP1g negatively regulates the germinal center and high-affinity antibody responses in a CD8+ T-cell-dependent manner. CD8-restricted deletion of Cbx3/HP1g confers hightened effector and persistence capacity on CD8+ effector T cells. As a result, Cbx3/HP1g-deficient CD8+ effector T cells can efficiently control solid tumor growth in vairious mouse models (melanoma, ovarian and neuroblstoma).

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Chromatin-associated RNAchIP and transcriptome analyses of the relationship between HP1g/CBX3 and RNA

Project description:This SuperSeries is composed of the SubSeries listed below.

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Cbx3 Maintains Lineage Specificity During Neural Differentiation [RNA-seq]

Project description:Cbx3 (HP1γ) that is a member of the heterochromatin protein 1 family play important roles in development and differentiation. To determine the regulatroy mechanisms of Cbx3 during neural differentiation from ESCs to NPCs, we performed RNA-seq analysis of ESCs or ESC-derived NPCs depleted for Cbx3 or Cbx3-assocatied Mediator subunit Med26.

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Expression data from pre-iPSCs with a control, histone methyltransferase or Cbx3 (HP1g) knockdown

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