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Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Sperm]

ABSTRACT: Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Sperm]

PROVIDER: PRJNA553001 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR9649770.fastq.gz	Fastqsanger.gz
	SRR9649761.fastq.gz	Fastqsanger.gz
	SRR9649771.fastq.gz	Fastqsanger.gz
	SRR9649762.fastq.gz	Fastqsanger.gz
	SRR9649772.fastq.gz	Fastqsanger.gz

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Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Sperm]

Project description:Obesity is a global rising problem with epidemiological dimension. Obese parents can have programming effects on their offspring leading to obesity and associated diseases in later life. This constitutes a vicious circle. Epidemiological data and studies in rodents demonstrated differential programming effects in male and female offspring, but the timing of their developmental origin is not known. This study investigated if sex-specific programming effects of parental obesity can already be detected in the pre-implantation period. Diet induced obese male or female mice were mated with normal-weight partners and blastocysts were recovered. Gene expression profiling revealed sex-specific responses of the blastocyst transcriptome to maternal and paternal obesity. The changes in the transcriptome of male blastocysts were more pronounced than those of female blastocysts, with a stronger impact of paternal than of maternal obesity. The sperm of obese mice revealed an increased abundance of several miRNAs compared to lean mice. Our study indicates that sex-specific programming effects of parental obesity already start in the pre‑implantation period and reveals specific alterations of the sperm miRNA profile as mechanistic link to programming effects of paternal obesity.

2019-07-07 | GSE133915 | GEO

Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Oocytes]

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Sex-specific programming effects of parental obesity in pre-implantation embryonic development_Microarray data on blastocyst transcriptomes

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Sex-specific programming effects of parental obesity in pre-implantation embryonic development

Project description:Sex-specific programming effects of parental obesity in pre-implantation embryonic development

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Project description:Sex-specific programming effects of parental obesity in pre-implantation embryonic development_small RNASeq Data of Sperm

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Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Oocytes]

Project description:Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Oocytes]

| PRJNA553002 | ENA

Sex-specific programming effects of parental obesity in pre-implantation embryonic development_Microarray data on blastocyst transcriptomes

Project description:Sex-specific programming effects of parental obesity in pre-implantation embryonic development_Microarray data on blastocyst transcriptomes

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Epigenetic programming of human sperm

Project description:Epigenetic programming of human sperm

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Epigenetic homogeneity underlies sperm programming for embryonic transcription

Project description:Epigenetic homogeneity underlies sperm programming for embryonic transcription single-ended ChIP-Seq libraries from sperm, egg extract (-geminin) treated sperm, egg extract (+geminin) treated sperm, and St 7 embryos with antibody for H3Kme3, H3K27me3, 3 replicates for each histone modification pull-down

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Sex-specific programming effects of parental obesity in pre-implantation embryonic development

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-07-07 | GSE133916 | GEO