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Evolutionary and Molecular Characterization of liver enriched gene 1

ABSTRACT: Evolutionary and Molecular Characterization of liver enriched gene 1

PROVIDER: PRJNA556809 | ENA |

REPOSITORIES: ENA

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Evolutionary and Molecular Characterization of liver enriched gene 1

Project description:Liver enriched gene 1 (Leg1) is a newly identified gene with few functional information. To know the function of Leg1 in mammals, a phylogenetic study was first conducted and indicated that Leg1 is an ancient gene, existing from bacteria to mammals. Analysis of pig genome shows the presence of three copies of pig Leg1s (pLeg1), which could be grouped to Leg1a, Leg1b, and Leg1c clades, respectively. Purifying force acts upon the evolution of Leg1 genes, making them highly likely be functional constraint.Additionally, expression analysis of pLeg1 in combination with the available expression data of human and mouse Leg1s suggests that the eutherian Leg1s might preserve similar function in contrary to those of zebrafish and platypus. Therefore, pLeg1a might provide essential information regarding eutherian Leg1a. In our work, pLeg1a and its coding protein pLEG1a display high similarities to its human and mouse counterparts in terms of gene organization, expression pattern, glycosylation, structures. Moreover, preliminary functional study using RNA-seq suggested that pLeg1a involves in the lipid homeostasis. In conclusion, our study has provided some basic information regarding the evolution, and function of Leg1 genes, which could be applied to further validation of Leg1.

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Evolutionary and Molecular Characterization of liver-enriched gene 1.

Project description:Liver-enriched gene 1 (Leg1) is a newly identified gene with little available functional information. To evolutionarily and molecularly characterize Leg1 genes, a phylogenetic study was first conducted, which indicated that Leg1 is a conserved gene that exists from bacteria to mammals. During the evolution of mammals, Leg1s underwent tandem duplications, which gave rise to Leg1a, Leg1b, and Leg1c clades. Analysis of the pig genome showed the presence of all three paralogs of pig Leg1 genes (pLeg1s), whereas only Leg1a could be found in the human (hLeg1a) or mouse (mLeg1a) genomes. Purifying force acts on the evolution of Leg1 genes, likely subjecting them to functional constraint. Molecularly, pLeg1a and its coded protein, pig LEG1a (pLEG1a), displayed high similarities to its human and mouse homologs in terms of gene organization, expression patterns, and structures. Hence, pLeg1a, hLeg1a, and mLeg1a might preserve similar functions. Additionally, expression analysis of the three Leg1as suggested that eutherian Leg1as might have different functions from those of zebrafish and platypus due to subfunctionalization. Therefore, pLeg1a might provide essential information about eutherian Leg1a. Moreover, a preliminary functional study using RNA-seq suggested that pLeg1a is involved in the lipid homeostasis. In conclusion, our study provides some basic information on the aspects of evolution and molecular function, which could be applied for further validation of Leg1 using pig models.

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